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GenomicsSUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer
SUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer
PRJNA1206089 | ENA
GenomicsCancer-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
Cancer-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
PRJNA528926 | ENA
GenomicsGenetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers
Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers
PRJNA668329 | ENA
ProteomicsProximity labelling and LCMSMS analysis of spliceosome complexes using SUGP1-miniTurbo
The purpose of the project is to identify proteins binding differentially to the human specific spliceosomal protein SUGP1 in the context of point mutations to its G-patch domain. SUGP1 wt and mutant (G603N or L570E) C-terminally tagged with mini-Turbo-NLS was overexpressed for 48 h in HEK293T cell...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD038067 | Pride
Spliceosome Sugp1 Proximity labeling Miniturbo Bioid 
UnknownSUGP1 is a novel regulator of cholesterol metabolism.
Not available
S-EPMC5181593 | biostudies-literature
OtherSUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer
SF3B1 is the most frequently mutated splicing factor in cancer. Such mutations cause missplicing by promoting aberrant 3' splice site usage; however, how this occurs mechanistically remains controversial. To address this issue, we employed a computational screen of 600 splicing-related proteins to i...
ORGANISM(S): Homo sapiens 
2025-07-03 | GSE285785 | GEO
UnknownSUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer.
Not available
S-EPMC12434867 | biostudies-literature
TranscriptomicsCancer-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
SF3B1, which encodes an essential spliceosomal protein, is frequently mutated in myelodysplastic syndromes (MDS) and many cancers. However, the defect of mutant SF3B1 is unknown. Here, we analyzed RNA-sequencing data from MDS patients and confirmed that SF3B1 mutants use aberrant 3' splice sites. To...
ORGANISM(S): Homo sapiens 
2019-07-24 | GSE128805 | GEO
TranscriptomicsGenetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers
RNA-sequencing data from HEK293T and HAP1 cell models: Hek293T (SF3B1-K700E, SF3B1-WT, SUGP1-KD and siContol), HAP1 CRISPR-isogenic cell lines WT and SUGP1-P636L
ORGANISM(S): Homo sapiens 
2020-10-10 | GSE159304 | GEO
UnknownDisease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1.
Not available
S-EPMC7065273 | biostudies-literature
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