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ProteomicsProteomic investigation of whole cortex and synaptosomes from rats with a familial Parkinson’s G51D mutation in the Snca gene.
The glycine-51 (G51) codon in exon 3 of the rat Snca gene, encoding alpha-synuclein, was mutated to aspartic acid using CRISPR/Cas9 to generate the SncaG51D rat model of Parkinson’s (Morley et al. 2023). The G51D mutation causes an aggressive form of Parkinson’s and dementia with Lewy bodies in huma...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-09-04 | PXD044776 | Pride
Parkinson's Alpha-synuclein Lewy pathology Synaptic dysfunction G51d mutation 
UnknownThe hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein.
Not available
S-EPMC8556266 | biostudies-literature
UnknownThe G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Not available
S-EPMC10155462 | biostudies-literature
UnknownIn vivo18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation.
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S-EPMC10244711 | biostudies-literature
UnknownThe novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
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S-EPMC4119404 | biostudies-literature
Unknownα-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
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S-EPMC3681325 | biostudies-literature
UnknownThe Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
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S-EPMC8879557 | biostudies-literature
UnknownGeneration of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.
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S-EPMC10904737 | biostudies-literature
UnknownOlfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice.
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S-EPMC11441490 | biostudies-literature
UnknownGlycine-to-aspartic acid mutation at codon 51 in <i>Snca</i> disrupts the synaptic localisation of α-synuclein and enhances its propensity for synucleinopathy.
Not available
S-EPMC12198753 | biostudies-literature
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