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ProteomicsIdentification of proteins stably associated with G9a/GLP (EHMT2/EHMT1) complex of histone methyltransferases
G9a (EHMT2) and the G9a-like protein GLP (EHMT1) form a stable G9a/GLP heterodimer in embryonic stem cells and function cooperatively to establish and maintain the abundant repressive H3K9me2 modification, in addition to modifying several non-histone proteins. The G9a-dependent H3K9me2 is implicated...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-16 | PXD003466 | Pride
Shotgun proteomics G9a/glp (ehmt2/ehmt1) complex Embryonic stem cells Histones Mouse Chromatin 
TranscriptomicsGene expression data from hippocampus, striatum, hypothalamus cortex, Drd2-MSNs and Drd1-MSNs in mice
Goal of the experiment: Analysis of gene expression changes in the cortex, striatum, hippocampus, hypothalamus, Drd2-MSNs and Drd1-MSNs of mice with a postnatal, neuron-specific ablation of GLP or G9a as compared to control mice. For microarray analysis, hippocampus, hypothalamus, cortex and striatu...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19402 | biostudies-arrayexpress
UnknownTNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1).
Not available
S-EPMC10215715 | biostudies-literature
UnknownInhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice.
Not available
S-EPMC5943902 | biostudies-literature
UnknownExon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects.
Not available
S-EPMC4233047 | biostudies-literature
TranscriptomicsHistone methylation by the Kleefstra Syndrome protein EHMT1 mediates homeostatic synaptic scaling.
Homeostatic plasticity, a form of synaptic plasticity, maintains the fine balance between overall excitation and inhibition in developing and mature neuronal networks. Although the synaptic mechanisms of homeostatic plasticity are well characterized, the associated transcriptional program remains po...
ORGANISM(S): Rattus norvegicus 
2016-06-30 | E-GEOD-68960 | biostudies-arrayexpress
TranscriptomicsExpression data from pre-iPSCs with a control, histone methyltransferase or Cbx3 (HP1g) knockdown
Transition from a partially reprogrammed pre-iPSC state to iPSC state can be achieved by modulating levels of histone modifying enzymes or proteins that can bind to histone modifications We used microarrays to determine the gene expression profile of pre-iPSCs depleted for either 3 histone methyltr...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-44084 | biostudies-arrayexpress
TranscriptomicsG9a influences neuronal subtype specification in striatum
Cocaine-mediated repression of the histone methyltransferase (HMT) G9a has recently been implicated in transcriptional, morphological, and behavioral responses to chronic cocaine administration. Here, using a ribosomal affinity purification approach, we find that G9a repression by cocaine occurs in ...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-54656 | biostudies-arrayexpress
UnknownEarly alteration of epigenetic-related transcription in Huntington's disease mouse models.
Not available
S-EPMC6028428 | biostudies-literature
TranscriptomicsMethylation profiling by array of mouse wild type and C9a knockout embyronic stem cells uisng antibodies against 5mC
Promoter DNA methylation in mouse ES cells (wild type and G9a knock-out) was assessed using an antibody against 5mC on fragmented genomic DNA and subsequent purification of the methylated DNA by affinity through a column containing the methyl-GpG binding domain of MeCP2 (MAP: methylation affinity pu...
ORGANISM(S): Mus musculus 
2010-08-25 | E-MEXP-2872 | biostudies-arrayexpress
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