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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsPhosphorylation of GABAAR α2 subunit
γ-aminobutyric acid type A receptors (GABAARs) mediate fast synaptic inhibition. Phosphorylation governs GABAARs function and trafficking in α4, β and γ subunits. However, phosphorylation of other subunits has not been demonstrated. Here we show that the α2 subunit is phosphorylated on S359.
ORGANISM(S): Mus musculus (Mouse) 
2020-07-03 | PXD019597 | Pride
Α2 Phosphorylation Gabaar 
UnknownBidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium.
Not available
S-EPMC4700050 | biostudies-literature
UnknownNovel GABAAR antagonists target networked gene hubs at the leading edge in high-grade gliomas.
Not available
S-EPMC12908485 | biostudies-literature
UnknownMultiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.
Not available
S-EPMC4183786 | biostudies-literature
UnknownKCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia.
Not available
S-EPMC8972932 | biostudies-literature
UnknownGABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex.
Not available
S-EPMC10602639 | biostudies-literature
UnknownAllopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.
Not available
S-EPMC6970471 | biostudies-literature
UnknownA Recombinant Human Pluripotent Stem Cell Line Stably Expressing Halide-Sensitive YFP-I152L for GABAAR and GlyR-Targeted High-Throughput Drug Screening and Toxicity Testing.
Not available
S-EPMC4923258 | biostudies-literature
UnknownThe female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons.
Not available
S-EPMC5886308 | biostudies-literature
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