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GenomicsLongitudinal DNA methylation profiling of individuals at baseline and 6 and 12 months following Gender Affirming Hormone Therapy (GAHT)
Longitudinal DNA methylation profiling of individuals at baseline and 6 and 12 months following Gender Affirming Hormone Therapy (GAHT)
PRJNA736069 | ENA
Methylation profilingLongitudinal DNA methylation profiling of individuals at baseline and 6 and 12 months following Gender Affirming Hormone Therapy (GAHT)
In individuals where gender identity and sex assigned at birth are markedly and consistently incongruent, as in the case of transgender people, feminisation or masculinisation may be sought through gender affirming hormone therapy (GAHT). In this study we profiled genome-wide DNA methylation in tran...
ORGANISM(S): Homo sapiens 
2022-02-17 | GSE176394 | GEO
ProteomicsPlasma Proteome adaptations in Feminising Gender Affirming Hormone therapy and Pregnancy
The dataset consists of longitudinal plasma proteomic data was generated using the Olink proteomics platform in plasma from transgender individuals receiving feminizing gender-affirming hormone therapy (GAHT). There were two treatment arms in the clinical trial that received different anti-androgens...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PAD000016 | Pride
Sex hormones Estradiol Gaht Pregnancy Sex Testosterone Gender Anti-androgen 
UnknownGender-affirming Hormone Therapy and Changes in Kidney Function in Adults: A Retrospective Population-based Study.
Not available
S-EPMC12309945 | biostudies-literature
Methylation profilingEpigenetics is implicated in the basis of gender incongruence. An epigenome-wide association analysis.
The main objective was to carry out a global DNA methylation analysis in a population with gender incongruence before gender-affirming hormone treatment (GAHT), in comparison to a cisgender population.
ORGANISM(S): Homo sapiens 
2021-04-27 | GSE173382 | GEO
Methylation profilingSix months of gender affirming hormone treatment modifies the methylome in the transgender population
The main objective was to carry out a prospective global CpG (cytosine-phosphate-guanine) methylation analysis before vs. after six months of gender affirming hormone treatment (GAHT), in a transgender population vs. a cisgender population.
ORGANISM(S): Homo sapiens 
2021-05-03 | GSE173717 | GEO
UnknownGender-affirming hormone therapy preserves skeletal maturation in young mice via the gut microbiome.
Not available
S-EPMC11093603 | biostudies-literature
TranscriptomicsExogenous Estrogen Enhances T Cell Activation in Male Primates
Estrogen influences T cell development and enhances infection resistance in females, but its immunological effects during gender-affirming hormone therapy (GAHT) remain poorly understood. Here we characterize immune adaptations in male rhesus macaques (RMs) treated with 17β-estradiol (E2) or placebo...
ORGANISM(S): Macaca mulatta 
2025-09-30 | GSE301415 | GEO
UnknownPrimary care provider beliefs and knowledge of prescribing gender-affirming hormone therapy to transgender and gender diverse patients.
Not available
S-EPMC11481314 | biostudies-literature
UnknownHormone Prescription and HIV Screening/Preventive Practices Among Clinicians Providing Care for Transgender Individuals.
Not available
S-EPMC9942173 | biostudies-literature
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