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Mass spectrometry is generally overlooked in the veterinary field despite the potential to yield significant and meaningful data with possible clinical implications. In this study, our team used mass spectrometry to investigate differences between the proteomic profile of a group of dogs diagnosed w...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-07-28 | PXD054409 | Pride
We assessed the impact of leaving a lyophilized mixture consisting of 125 peptides at room temperature for up to 20 days, and we assessed the effect on the quantitative performance of multiple reaction monitoring-MS (MRM-MS) assays. The findings suggest that there are no significant differences in t...
ORGANISM(S): Homo Sapiens 
2022-09-05 | PXD028179 | panorama
When using a mix of 274 light synthetic peptide standards as surrogates for 270 human plasma proteins, as well as stable isotope-labelled standards as normalizers for targeted quantitative analysis by LC/MRM-MS, the Seer Proteograph allowed for the enrichment and absolute quantitation of up to an ad...
ORGANISM(S): Homo Sapiens 
2025-02-17 | PXD053704 | panorama
Here, we investigate how delays in plasma processing affect peptide-centric “bottom-up” proteomics, using multiple reaction monitoring mass spectrometry (MRM-MS). We used validated Tier 2-level assays for proteotypic peptide surrogates of 270 human proteins to analyze plasma generated from whole bl...
ORGANISM(S): Homo Sapiens 
Molecular signatures to discriminate patients based on risk of severe disease and mortality from COVID-19 infection are urgently required by the global medical community. Although non-targeted methods are useful for comprehensive ‘omic coverage, targeted MS-based approaches generally provide higher ...
ORGANISM(S): Homo Sapiens 
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