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MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
MetabolomicsAtractylodin targets ASAH3L to regulate galactose metabolism and thereby modulates the HIF-1 signaling pathway for the treatment of acute lung injury

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

2024-07-23 | MTBLS9948 | MetaboLights
MetabolomicsHuman NK vs T cell metabolism using 13C-Glucose tracer with/out galactose (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000950 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of galactose-grown S. cerevisiae cells exposed to lithium chloride
Wild type strain CEN.PK113-7D was grown in an aerobic batch cultivation with a start concentration of 20 g/L galactose. During exponential growth at a biomass concentration of 3 g dry weight/L LiCl was added to a concentration of 10 mM. Just before addition of LiCl (time 0) and 20, 40, 60 and 140 mi...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-461 | biostudies-arrayexpress
MetabolomicsHuman NK vs T cell metabolism using 13C-Glucose tracer with/out oligomycin and galactose (part IV)
Not available
ORGANISM(S): Homo sapiens 
ST000952 | MetabolomicsWorkbench
TranscriptomicsSystem level characterization of galactose mutants of yeast
Adaptively evolved mutants of yeast on galactose were characterized by feremtation physiology and tools from systems biology. Three evolved mutants of yeast grown on aerobic batch with galactose as carbon source
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-31 | E-GEOD-27185 | biostudies-arrayexpress
ProteomicssRNA-mediated crosstalk between cell wall stress and galactose metabolism in Staphylococcus aureus
Staphylococcus aureus is an opportunistic pathogen responsible for a wide range of diseases in humans. During infections, this bacterium is exposed to various stresses that target its cell wall, such as oxidative or acid environments as well as various cell wall-acting antimicrobials. S. aureus has ...
ORGANISM(S): Staphylococcus aureus 
2025-07-28 | PXD060402 | Pride
Small rna regulation Galactose metabolism Acidic stress Staphylococcus aureus 
TranscriptomicsJM43 cells grown aerobically in galactose and treated with Antimycin A
In previous temporal studies, we found the anaerobic response was biphasic when cells growing in galactose medium were shifted from aerobiosis to anaerobiosis, consisting of an acute, transitory phase (<60 min) followed by a more chronic but delayed phase (> 1 generation), but largely monophasic (de...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-31 | E-GEOD-3705 | biostudies-arrayexpress
TranscriptomicsMetabolism of four α-glycosidic linkage-containing oligosaccharides by Bifidobacterium breve UCC2003
Members of the genus Bifidobacterium are common inhabitants of the gastrointestinal tract of humans and other mammals, where they ferment many diet-derived carbohydrates that cannot be digested by their host. To extend our understanding of bifidobacterial carbohydrate utilisation, we investigated th...
ORGANISM(S): Bifidobacterium breve 
2013-08-16 | E-GEOD-47448 | biostudies-arrayexpress
MetabolomicsPlanting Density Affects Panax notoginseng Growth and Ginsenoside Accumulation by Balancing Primary and Secondary Metabolism
Adjusting planting density is a common agricultural practice used to achieve maximum yields. However, whether the quality of medicinal herbs can be improved by implementing appropriate planting densities is still uncertain. The medicinal crop Panax notoginseng was used to analyze the effects ...
2021-07-15 | MTBLS2634 | MetaboLights
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