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GenomicsTranscriptomics revealed the putative mechanism underlying the impact of HFL1 fibroblasts with overexpression of GALC on LoVo cell
Transcriptomics revealed the putative mechanism underlying the impact of HFL1 fibroblasts with overexpression of GALC on LoVo cell
PRJNA607910 | ENA
UnknownGALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.
Not available
S-EPMC10151180 | biostudies-literature
UnknownHigh Prevalence of GALC Gene Variants in Adults With Neurodegenerative Conditions.
Not available
S-EPMC12090362 | biostudies-literature
ProteomicsQuantification profiles of enzyme activity, secretion and psychosine levels of Krabbe disease galactosylceramidase missense variants
Krabbe disease (KD) is an autosomal recessive lysosomal storage disorder caused by loss-offunction mutations in the GALC gene, which encodes for the enzyme galactosylceramidase (GALC). GALC is crucial for myelin metabolism. Functional deficiency of GALC leads to toxic accumulation of psychosine, dys...
ORGANISM(S): Homo sapiens (Human) 
2025-05-19 | PXD057472 | Pride
Secretion Missense mutation variant Galactosylceramidase Lysosomal storage disorder Lysosome Galc Psychosine Crispr-cas9 knockout cell Protein trafficking Krabbe disease Expression study Genotype-phenotype correlation Galactosylsphingosine Globoid cell leukodystrophy 
TranscriptomicsTranscriptomics revealed the putative mechanism underlying the impact of HFL1 fibroblasts with overexpression of GALC on LoVo cell
Purpose:To elucidate the mechanism by which overexpression of GALC senescent fibroblasts promote the tumor properties of LoVo CRC cells Methods: LoVo cell which co-cultured with LV-GALC HFL1 fibroblasts cells and LoVo cell which co-cultured with LV-NC HFL1 fibroblasts cells using Transwell chamber w...
ORGANISM(S): Homo sapiens 
2020-02-25 | GSE145662 | GEO
UnknownIdentification and characterization of 15 novel GALC gene mutations causing Krabbe disease.
Not available
S-EPMC3052420 | biostudies-literature
UnknownGALC Triggers Tumorigenicity of Colorectal Cancer via Senescent Fibroblasts.
Not available
S-EPMC7154132 | biostudies-literature
UnknownMacrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction.
Not available
S-EPMC7924901 | biostudies-literature
UnknownHeterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.
Not available
S-EPMC5886101 | biostudies-literature
UnknownGALC mutations in Chinese patients with late-onset Krabbe disease: a case report.
Not available
S-EPMC6560759 | biostudies-literature
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