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TranscriptomicsTranscription profiling of human monocyte derived dendritric cells matured with Galectin-1 or LPS vs controls
Human monocyte derived dendritic cells matured via galectin-1 or LPS. Experiment Overall Design: 4 conditions with 3 replicates of each include control or intreated immature MDDCS, galectin-1 treated MDDCs, LPS treated MDDCs, and vehicle control MDDCs. (each replicate is from a distinct DONOR). Dend...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4984 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts
In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to pre...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-MTAB-850 | biostudies-arrayexpress
TranscriptomicsGalectin-1 couples glycobiology to inflammation in osteoarthritis through the activation of an NF-κB-regulated gene network
Osteoarthritis is a degenerative joint disease that ranks among the leading causes of pain, adult disability, shortening of working life, and socioeconomic costs worldwide. The mechanisms underlying osteoarthritis pathogenesis are yet to be fully elucidated, thus limiting current disease management ...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-68760 | biostudies-arrayexpress
ProteomicsGalectin-1 and Galectin-3 interactors
Identification of interactors is a major attempt in cell biology. Not only protein-protein but also protein-carbohydrate interactions are of high relevance for signal transduction in biological systems. Here we aim to identify novel interacting binding partners for the β-galactoside-binding proteins...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD005461 | Pride
Interactors Galectin Pull-down Retina 
ProteomicsGalectin-1 Treated A/J muscle cells
Galectin-1 is being used as potential therapeutic to alleviate the progression onset of pathologies exhibited in Limb Girdle Muscular Dystrophy Type 2B.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-27 | MSV000085835 | MassIVE
ProteomicsTargeting the Galectin-7/TRPM2/Zn2+/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN
Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 signaling pathway in keratinocyte presents a prospective therapeutic strategy for mitigating SJS/TEN in the future.
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059206 |
GenomicsInnate immune function of galectin-1 as a DAMP
Innate immune function of galectin-1 as a DAMP
PRJNA591290 | ENA
ProteomicsPhosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling
we applied label-free quantitative phosphoproteomic analysis to delineate the dynamics of galectin-1-induced signaling in comparison with the first systematic phosphorylation-mediated signaling network in B cell activation by anti-IgM treatment.
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD000762 | Pride
B-cell receptor Phosphoproteome Galectin-1 B-cell activation Lc-ms/ms 
GenomicsGalectin-1-RNA interaction map reveals its novel regulatory roles in angiogenesis
Galectin-1-RNA interaction map reveals its novel regulatory roles in angiogenesis
PRJNA615386 | ENA
GenomicsOligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in inflammatory bowel disease
Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in inflammatory bowel disease
PRJNA564946 | ENA
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