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ProteomicsFasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism
Cancer cells voraciously consume nutrients to support their growth, exposing a metabolic vulnerability that can be therapeutically exploited. Here we show in hepatocellular carcinoma (HCC) cells, xenografts, and in patient-derived HCC organoids that fasting can synergistically sensitise resistant HC...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-16 | PXD022723 | Pride
Xenografts Starvation Hcc Sorafenib Tp53 Hepg2 
ProteomicsProximity-biotinylation (BioID) to dissect cytoplasmic p53 signaling networks under nutrient stress
p53 signaling is a major response mechanism to cellular stresses through cytoplasmic or nuclear action. While p53 protein levels have been shown to increase upon nutrient stresses such as starvation, the exact signaling cascade in this context remains elusive. Here, we use proximity biotinylation (B...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027734 | Pride
Nutrient stress Starvation P53 signaling Bioid Interactome 
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