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MetabolomicsBMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study, we furthe...
2025-01-24 | MTBLS11557 | MetaboLights
TranscriptomicsTranscriptome analysis of zebrafish heart exposed to sorafenib
Sorafenib is associated with cardiac adverse effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish the genes responsible for this cardiotoxicity using zebrafish. A pigmentless zebrafish line expressing green fluorescent protein i...
ORGANISM(S): Danio rerio 
2014-12-04 | E-GEOD-61155 | biostudies-arrayexpress
TranscriptomicsLong-term Exposure to Sorafenib of Liver Cancer Cells Induces Resistance with Epithelial-to-Mesenchymal Transition, Increased Invasion and Risk of Rebound Growth
Sorafenib leads to a survival benefit in patients with advanced hepatocellular carcinoma but its use is hampered by the occurrence of drug resistance. To investigate the molecular mechanisms involved we developed five resistant human liver cell lines in which we studied morphology, gene expression a...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-62813 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib
Relapsed/refractory Hodgkin lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65483 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HDLM-2 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib
Relapsed/refractory Hodgkin lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65479 | biostudies-arrayexpress
TranscriptomicsWhole genome profiling of whole liver lysates of vehicle and Sorafenib-treated iAST mice
Analysis of changes in gene expression upon Sorafenib treatment. Looking for candidates, that could potentially be up- or down-regulated upon Sorefanib treatment. Total RNA were optained from whole liver lysates of vehicle 14d-, Sorafenib 14d- and LT Sorafenib-treated iAST mice
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-54857 | biostudies-arrayexpress
ProteomicsPhosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 AML Cells
Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, application of FLT3 small molecule inhibitors such as ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD004442 | Pride
Phosphoproteomics Sorafenib Flt3 Acute myeloid leukemia 
TranscriptomicsFeasibility of global microRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib
Tumor cells were microdissected from FFPE sections of hepatocellular carcinoma (HCC) samples. micro RNA expression were correlated to clinical outcome and sorafenib-therapy. miRNA was labeled with the Affymetrix FlashTag Biotin HSR RNA Labeling Kit 20 microdissected hepatocellular carcinoma samples ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-56059 | biostudies-arrayexpress
TranscriptomicsTranscriptomic study of hepatocarcinoma cells exposed to sorafenib
sorafenib is the treatment of reference for hepatocellular carcinoma (HCC). We applied sorafenib on the human HCC cell line Huh7 and the subclone shRb, carrying a stable knock-down of the expression of the RB1 gene, a key regulator of liver carcinogenesis. Our aim was to better understand the physio...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-75620 | biostudies-arrayexpress
TranscriptomicsTUMOR INITIATING CELLS AND IGF/FGF SIGNALING CONTRIBUTE TO SORAFENIB RESISTANCE IN HEPATOCELLULAR CARCINOMA
OBJECTIVE: Sorafenib is effective in hepatocellular carcinoma (HCC), but patients ultimately present disease progression. Molecular mechanisms underlying acquired resistance are still unknown. Herein, we characterize the role of tumor-initiating cells (T-ICs) and signaling pathways involved in soraf...
ORGANISM(S): Homo sapiens 
2016-06-16 | E-GEOD-73571 | biostudies-arrayexpress
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