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ProteomicsThe cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism
Some molecular chaperones are involved not only in assisting the folding of proteins but also, given appropriate conditions, in their degradation. This is the case of Hsp70 and Hsp90, which direct their bound substrate to degradation through ubiquitination in concert with the cochaperone CHIP –an E...
ORGANISM(S): Homo sapiens (Human) 
2019-03-07 | PXD009756 | Pride
Shotgun Dsso Crosslinking 
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells
This SuperSeries is composed of the following subset Series: GSE31255: Isolation and in vitro expansion of human colonic stem cells [Expression profile] GSE31256: Isolation and in vitro expansion of human colonic stem cells [CGH] Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31257 | biostudies-arrayexpress
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [CGH]
Tissue for normal colonic stem cell isolation was obtained via colectomy from a colorectal cancer patient. It was shown that the resected tissue and the in vitro-cultured organoids grown from tissue-derived adult stem cells do not harbor chromosomal alterations. For that purpose, genomic DNA from re...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31256 | biostudies-arrayexpress
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [Expression profile]
Using the surface marker EPHB2, we have FACS-purified and profiled stem cell-enriched cell fractions from normal human mucosa, crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal human colon epithelial stem cells We FACS purifie...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31255 | biostudies-arrayexpress
UnknownImmunogenicity and safety assessment of a SARS-CoV-2 recombinant spike RBD protein vaccine (Abdala) in paediatric ages 3-18 years old: a double-blinded, multicentre, randomised, phase 1/2 clinical trial (ISMAELILLO study).
Not available
S-EPMC10462868 | biostudies-literature
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