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This experiment was conducted to identify the mitochondrial protein changes in the presence and absence of LONP1 in skeletal muscle. The following abstract from the submitted manuscript describes the major findings of this work.Disuse-associated loss of muscle LONP1 impairs mitochondrial quality and...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-05 | PXD029722 | Pride
Liver fibrosis is an urgent clinical problem without effective treatment. Herein, we conducted a high-content screening on a natural “privileged” diterpenoid library to identify a potent anti-liver fibrosis lead DP. Leveraging photoaffinity labeling approach, apolipoprotein L2 (APOL2), an ER-rich pr...
ORGANISM(S): Homo sapiens (Human) 
2024-08-13 | PXD047924 | Pride
Mycosis fungoides (MF) is the most common T-cell lymphoma in cutaneous malignant lymphoma, which may involve multiple organs in the advanced stage with a poor prognosis. Till now, early identification of the disease is still urgent and also there is no optimal therapy for advanced MF. In the present...
ORGANISM(S): Homo sapiens (Human) 
2021-11-23 | PXD027714 | Pride
To investigate the functional role of APOL2 in liver fibrosis, we performed an unbiased immunoprecipitation-mass spectrometry (IP-MS) analysis for APOL2 in the TGF-β1-stimulated LX-2 cell lysates.
ORGANISM(S): Homo sapiens (Human) 
2024-08-13 | PXD047815 | Pride
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