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GenomicsSialidaseNeu3action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis
SialidaseNeu3action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis
PRJNA1010227 | ENA
TranscriptomicsSialidaseNeu3action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis
GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in theGLB1gene, which encodes lysosomalb-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ganglioside (GA1 glycolipid) in brain. This disease can pr...
ORGANISM(S): Mus musculus 
2023-12-14 | GSE241844 | GEO
ProteomicsDeficiency of the frontotemporal dementia gene GRN results in gangliosidosis
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unclear. Here we discover that PGRN-deficient human c...
ORGANISM(S): Homo sapiens (Human) 
2022-09-18 | PXD035889 | Pride
Haploinsufficiency Lysosome Bmp Pgrn Frontotemporal dementia Gangliosides 
UnknownGM1 Gangliosidosis-A Mini-Review.
Not available
S-EPMC8446533 | biostudies-literature
UnknownBrain Age Prediction in Type II GM1 Gangliosidosis.
Not available
S-EPMC12045421 | biostudies-literature
UnknownClinical findings in Brazilian patients with adult GM1 gangliosidosis.
Not available
S-EPMC6718113 | biostudies-literature
UnknownNatural history of infantile G(M2) gangliosidosis.
Not available
S-EPMC3208966 | biostudies-literature
UnknownSkeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats.
Not available
S-EPMC8851500 | biostudies-literature
UnknownCanine GM2-Gangliosidosis Sandhoff Disease Associated with a 3-Base Pair Deletion in the HEXB Gene.
Not available
S-EPMC5787214 | biostudies-literature
UnknownCharacterization of glycan substrates accumulating in GM1 Gangliosidosis.
Not available
S-EPMC6838976 | biostudies-literature
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