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UnknownClassic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.
Alzheimer's disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug thera...
S-EPMC6636599 | biostudies-literature
UnknownDuhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration.

Background

Articular cartilage and cartilage matrix degradation are key pathological changes occurring in the early stage of knee osteoarthritis (KOA). However, currently, there are limited strategies for early prevention and treatment of KOA. Duhuo Jisheng Decoction (DHJSD) is a formula quo...
S-EPMC10760926 | biostudies-literature
UnknownJordan syndrome due to <i>PPP2R5D</i> gene mutation: a report of two pediatric cases and literature review.

Background

Jordan syndrome is a rare neurodevelopmental disorder caused by mutations in the PPP2R5D gene. It is characterized by developmental delay, macrocephaly, hypotonia, epilepsy, and autism spectrum disorder. This study aims to enhance clinical recognition of the disease by pres...
S-EPMC12683426 | biostudies-literature
UnknownThe two-component system CpxA/CpxR is critical for full virulence in Actinobacillus pleuropneumoniae.
Actinobacillus pleuropneumoniae, a major bacterial porcine respiratory tract pathogen causing pig pleuropneumonia, has resulted in high economic losses worldwide. The mutation of the two-component system CpxAR strongly impacted the virulence of A. pleuropneumoniae, but the underlying r...
S-EPMC9615922 | biostudies-literature
UnknownThe two-component system CpxAR is required for the high potassium stress survival of Actinobacillus pleuropneumoniae.

Introduction

Actinobacillus pleuropneumoniae is an important respiratory pathogen, which can cause porcine contagious pleuropneumonia and lead to great economic losses to worldwide swine industry. High potassium is an adverse environment for bacteria, which is not conducive to providing turg...
S-EPMC10562621 | biostudies-literature
UnknownThe CpxA/CpxR two-component system mediates regulation of Actinobacillus pleuropneumoniae cold growth.

Introduction

To survive in various hostile environments, two-component system is an adaptive mechanism for diverse bacteria. Activity of the CpxA/CpxR two-component system contributes to coping with different stimuli, such as pH, osmotic and heat stress.

Methods

However, the role of t...
S-EPMC9816388 | biostudies-literature
UnknownHIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.
Inhibition of pathological cardiac hypertrophy is recognized as an important therapeutic strategy for heart failure, although effective targets are still lacking in clinical practice. Homeodomain interacting protein kinase 1 (HIPK1) is a conserved serine/threonine kinase that can respond to differen...
S-EPMC10288234 | biostudies-literature
OtherThe Tissue-Based Proteogenomics Reveals that Human Testis Endows Plentiful Missing Proteins.
Data from ProteomeXchange, PXD ID: PXD002179. Experiment: CHPP_TESTIS_Tricine, file: CHPP_TESTIS_Tricine_2017.mgf. Published as part of J Proteome Res. 2015 . From the Abstract: {{i}} Investigations of missing proteins (MPs) are being endorsed by many bioanalytical strategies. We proposed that prot...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310023526 | GPMDB
Resource Reanalysis 
ProteomicsEnrichment strategy for searching missing protein
Enrichment strategy for searching missing protein is a project under the guidance of Chromosome-Centric Human Proteome Project (C-HPP). We developed systematical enrichment strategies for revealing the existence of MPs including low molecular weight (LMW), membrane proteins, post-translational modif...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083957 | MassIVE
ProteomicsCN-CHPP 2015 Testis Project
The testis tissue-based trans-omics was a feasible approach to find more missing proteins (MPs) because it was reported higher gene expression found in testis tissues. Three testis tissues and two protein separation strategies were selected to quantitatively evaluate gene expression abundance at the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-26 | MSV000082510 | MassIVE
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