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ProteomicsHuman prostate cancer and Lysine succinylation
: Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Using quantitative global succinylome analysis, we characterized a significant increase of ly...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD022005 | Pride
Prostate cancer Lysine succinylation Metastasis 
ProteomicsProximity labeling – LC/MS-MS with ERC1-TurboID/atg7-2 Arabidopsis seedlings
Given that ERC1 proteins are enriched on membraneless condensates together with ATG8 proteins prior to autophagosome formation, we hypothesized that ERC1-positive condensates might serve as an assembly site for ATG8 proteins and other adaptors before ATG8 proteins are conjugated onto the phagophore ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-07 | PXD067354 | Pride
Erc protein family Atg8 Turboid Biomolecular condensation Autophagosome formation 
ProteomicsProximity labeling – LC/MS-MS with TurboID-ATG8e/atg2-1 Arabidopsis seedlings
By employing a proximity labeling approach using Arabidopsis ATG8e tagged with TurboID as bait in atg2-1 background, we discovered a protein family of unknown function, consisting of two homologs (AT4G02880 and AT1G03290). Both proteins contain coil-coiled domains that are predicted to be closely re...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-07 | PXD067352 | Pride
Turboid Vesicle secretion Ap-ms 
ProteomicsClinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion
Vascular invasion is considered as the critical risk factors for tumor recurrence of hepatocellular carcinoma (HCC). To reveal the molecular mechanisms underlying macrovascular invasion (MaVI) and metastasis in HCC, we performed an iTRAQ based proteomic study to identify notably dysregulated protein...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD011846 | Pride
Hcc  macorvascular invasion  itraq  urea cycle  proteomic signature  molecular mechanisms. 
ProteomicsThe Histone Acetyltransferase MOZ is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML), and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However, the composition and consequences of NUP98 FO-associated condensates are incompletely understood. H...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058286 | Pride
Histone acetyltransferase Gene fusion Leukemia Nup98 
ProteomicsThe EN-TEx Resource for Personal Functional Genomics
An overall goal of functional genomics has been to measure the impact of variants on molecular endophenotypes (e.g. gene expression levels or the degree of TF binding) and relate this to organismal traits and disease phenotypes. However, all the experiments to date have been described relative to a ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD022787 | Pride
Personal genomics Tmt Human Proteogenomics Tissue En-tex 
UnknownScalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
Not available
S-EPMC6075717 | biostudies-literature
UnknownHIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.
Not available
S-EPMC12639139 | biostudies-literature
UnknownComparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Not available
S-EPMC5966039 | biostudies-literature
UnknownMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.
Not available
S-EPMC10762575 | biostudies-literature
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