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UnknownGut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
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S-EPMC9241845 | biostudies-literature
TranscriptomicsAKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo
Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). Its interaction with estrogen receptor (ER) signalling becomes more complex and inter-dependent with acquired endocrine resistance. Targeting mTOR combine...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-69893 | biostudies-arrayexpress
TranscriptomicsDifferences in the Transcriptional Response to Fulvestrant and Estrogen Deprivation in ER-Positive Breast Cancer
Aromatase inhibitors are first-line postmenopausal agents for estrogen receptor alpha (ERa)-positive breast cancer. However, there is considerable response heterogeneity and women frequently relapse. Estrogen deprivation does not completely arrest ERa activity, and transactivation of the unliganded ...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-71791 | biostudies-arrayexpress
TranscriptomicsGDNF-RET signaling as a target in aromatase inhibitor resistant breast cancers
Understanding the complex molecular mechanisms underlying resistance to endocrine therapy is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancers. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) signaling via the receptor tyros...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3662 | biostudies-arrayexpress
ProteomicsConotoxin Exploitation from Conus betulinus
Employing Conus betulinus as a representative, we sequenced and assembled the first Conus genome. After integration of multi-omics data, we provide novel insights into the genetic central dogma of conotoxins, assuming a number ratio of ~1:1:10s for genes/transcripts/peptides.
ORGANISM(S): conus betulinus 
2021-09-08 | PXD014892 | Pride
Conus  genome  conotoxins  multi-omics  transcript  proteomics  peptide 
ProteomicsAndrogen Rapidly Activates Phosphorylation Signaling Pathways in Sertoli Cells
This study comprehensively analyzed androgen-activated phosphorylation signaling pathways in testicular Sertoli cells. Primary cultured mouse Sertoli cells were treated with testosterone for varying durations. Using Tandem Mass Tag (TMT)-labeled phosphoproteomics technology combined with Mfuzz clust...
ORGANISM(S): Mus Musculus 
PXD078604 |
ProteomicsCleavable Hydrophobic Derivatization Strategy for Enrichment and Identification of Phosphorylated Lysine Peptides
Herein, a cleavable hydrophobic derivatization (CHD) strategy was established for the enrichment and identification of pLys peptides. By CHD, 2,5-dioxopyrrolidin-1-yl-3-(decyldisulfanyl)propanoate (Dec-disulf-NHS) was synthesized to react with lysine dephosphorylated peptides, and then the derived p...
ORGANISM(S): Escherichia Coli 
2019-02-12 | PXD012682 |
ProteomicsMulti-omics profiling identifies pathways associated with CD8+ T cell activation in severe aplastic anemia
plasma of SAA patients (n = 14) and healthy donors (n =15)
ORGANISM(S): Homo Sapiens 
PXD029024 |
ProteomicsiTRAQ-based proteomic analysis of Deinococcus radiodurans in response to 12C6+ heavy ions irradiation
Proteome of Deinococcus radiodurans which were treaded by four different doses of heavy ion radiation.
ORGANISM(S): Deinococcus Radiodurans R1 
2022-02-28 | PXD031902 |
ProteomicsAn integrative multi-omics approach uncovers the regulatory role of Cdk7 and Cdk4 in autophagy induced by silica nanoparticles
The abnormal induction of macroautophagy/autophagy, a highly conserved lysosome-based degradation pathway, has been postulated as a major toxicity of nanomaterials, whereas little is known on the exact molecular mechanisms. Here, we treated mammalian cells with 16 nm silica nanoparticles (SiNPs), co...
ORGANISM(S): Rattus Norvegicus 
2019-12-01 | PXD012196 |
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