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MetabolomicsKidney Tissue Targeted Metabolic Profiling of Unilateral Ureteral Obstruction Rats by NMR
Renal interstitial fibrosis is a common pathological process in the progression of kidney disease. A nuclear magnetic resonance (NMR) based metabolomics approach was used to analyze the kidney tissues of renal interstitial fibrosis (RIF) rats, induced by unilateral ureteral obstruction (UUO). The co...
2017-10-09 | MTBLS361 | MetaboLights
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsProteomic analysis of the invasiveness of human bladder cancer cells
To identification of key drivers involved in the development of muscle invasive bladder cancer, which displays poor prognosis, we isolated one subpopulation of human 5637 bladder cancer cells with highly invasiveness and the other subpopulation of 5637 cells with low invasiveness by Transwell method...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-27 | MSV000082854 | MassIVE
ProteomicsMulti-in-One: Multiple-proteases, One-hour-shot Strategy for Fast and High-coverage Phosphoproteome
a ‘multi-in-one’ strategy to saturate the phosphosite coverage from multiple-proteases by one-step enrichment and one-shot analysis in just over one hour, through data-independent acquisition (DIA)
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-06-07 | PXD019320 |
ProteomicsProteomic Profiling and Biomarker Discovery for Predicting Response to PD-1 Inhibitor Immunotherapy in Gastric Cancer Patients
Revolutionizing cancer treatment, immune checkpoint inhibitors (ICIs) have nonetheless encountered a challenge: a substantial portion of gastric cancer (GC) patients don’t respond to this therapy. This pressing issue necessitates a deeper understanding of the resistance mechanisms against ICIs and t...
ORGANISM(S): Homo Sapiens 
2024-02-29 | PXD050228 |
ProteomicsPan-analysis of Single Amino-acid Polymorphism
Uncovering dark mass in population proteomics: Pan-analysis of Single Amino-acid Polymorphism (Pan-SAP) revealed quantitative relevance with cognition and aging
ORGANISM(S): Homo Sapiens 
2024-12-31 | PXD059327 |
ProteomicsTMT-based LC-MS/MS proteomics of cholesteatoma
Eight cases of middle ear cholesteatoma specimens and matched ear canal skin specimens
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD036926 |
ProteomicsTotal and mitochondrial transcriptomic and proteomic insights into energy regulation mechanism for shoot fast growth initiation in Moso bamboo(Phyllostachys edulis)
Moso bamboo (Phyllostachys edulis) is one of the fast-growing plant species and has high comprehensive utilization value. However, how Moso bamboo realize the transition from initial growth of winter shoot to fast growth of spring shoot is still unknown. Large increase of biomass in spring shoot sug...
ORGANISM(S): Phyllostachys Edulis 
PXD028178 |
ProteomicsProteomic profiling and tumor microenvironment characterization reveal molecular and immunological hallmarks of left-sided and right-sided colon cancer tumorigenesis
The protein landscapes of LSCC and RSCC were constructed, and the hallmarks of tumorigenesis and characteristics of TME for LSCC and RSCC were identified. These findings improved our understanding of LSCC and RSCC and may facilitate the development of diagnostic or therapeutic targets for LSCC and R...
ORGANISM(S): Homo Sapiens 
PXD042962 |
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