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ProteomicsMapping the anti-cancer activity of alpha-connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer
Connexin 43 (Cx43) is a protein encoded by the GJA1 gene and is a component of cell membrane structures called gap junctions, which facilitate intercellular communication. Prior evidence indicates that elevated GJA1 expression in the HER2-positive (HER2+) subtype of breast cancer is associated with ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-01 | MSV000093550 | MassIVE
ProteomicsTMT analysis of flagellum skeletons from MIP knockdown parasites
TMT data associated with Shimogawa et al. 'FAP106 is an interaction hub required for stable assembly of conserved and lineage-specific proteins at the cilium inner junction'
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-07 | MSV000090661 | MassIVE
GenomicsNeuronal Acetylcholine Couples Gonadal Gap Junction/Notch Signaling Axis to Gut Defense
Neuronal Acetylcholine Couples Gonadal Gap Junction/Notch Signaling Axis to Gut Defense
PRJNA896101 | ENA
TranscriptomicsTranscription profiling of mouse to identify strain-specific variation and the onset of gap junction mutation-induced cataractsc
Disruption of the mouse gene encoding the gap junction subunit alpha3 connexin 46 (Cx46) results in the formation of lens cataracts. The timing of the onset of this lens opacity is affected by the genetic background, i.e. the mouse strain. To elucidate the mechanism by which cataracts form in the 12...
ORGANISM(S): Mus musculus 
2009-05-11 | E-GEOD-5645 | biostudies-arrayexpress
ProteomicsCo-IP (AP-MS) of Connexin-43 - Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Co-IP Experiment Bait: Cx43-Flag Cell line: Hela Related Publication: Gap Junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo, Maria Kotini, Elias Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambony, and Roberto Mayor
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010870 | Pride
Ap-ms Hela Co-ip 
ProteomicsAPEX2 proximity proteomics of microtubule inner proteins FAP45 and FAP52
APEX2-based proximity proteomics data associated with Shimogawa et al. 'FAP106 is an interaction hub required for stable assembly of conserved and lineage-specific proteins at the cilium inner junction'
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-07 | MSV000090660 | MassIVE
TranscriptomicsExpression data from mouse whole bladders of cyclophosphamide-induced cystitis
To analyze the gene expression of non-bacterial bladdder inflammation, mouse cyclophosphamide(CYP)-induced model of cystitis was adapted. Forty-eight hour after CYP or vehicle treatment, total RNA was extracted from CYP-treated group (CYP150) and control group (CYP0). We used microarrays to detail t...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-55986 | biostudies-arrayexpress
TranscriptomicsNeuronal Acetylcholine Couples Gonadal Gap Junction/Notch Signaling Axis to Gut Defense
Gap junctions mediate intercellular communications across cellular networks in the nervous and the immune systems, while the role in the intestinal innate immunity is poorly understood. Here, we identified that an innexin gene inx-14 encoding one of heterotypic and heteromeric gap junction subunits ...
ORGANISM(S): Caenorhabditis elegans 
2023-11-01 | GSE216879 | GEO
ProteomicsDysregulation of Cell-Cell Interaction in Brain Arteriovenous Malformations: A Quantitative Proteomics Study
Object. Detailed and exact mechanisms underlying brain arteriovenous malformations (bAVM) are still confusing in clinic. Understanding the quantitative changes of proteins and signaling pathways would provide useful information for clinicians to understand the formation and development of bAVM and t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080716 | MassIVE
TranscriptomicsCX43 KO vs WT cortical astrocytes
RNA samples extracted from astrocytes cultured from wild type and Cx43 null neonatal mice were dye labeled and individually co-hybridized with a reference of labeled cDNAs pooled from a variety of tissues on eight gene arrays containing 8975 mouse DNA sequences
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-580 | biostudies-arrayexpress
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