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UnknownUnidirectional association of clonal hematopoiesis with atherosclerosis development.
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher risk of hematological cancer and a growing list of nonhematological disorders, most notably atherosclerosis and associa...
S-EPMC11485253 | biostudies-literature
UnknownSubclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study.

Aims

Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association.

Methods ...

S-EPMC10393076 | biostudies-literature
UnknownExperimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease.
Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) resulting from the interaction of multiple environmental, genetic and immunological factors. CD5 and CD6 are paralogs encoding lymphocyte co-receptors involved in fine-tuning intracellular signals de...
S-EPMC9532939 | biostudies-literature
UnknownThe international PIACO study: pattern of surgical approaches for acute surgical pathologies in Spain versus UK. Was conservative treatment and open surgery during COVID-19 the way to go?
Not available
S-EPMC9359448 | biostudies-literature
UnknownAn Acute Stress Scale for Health Care Professionals Caring for Patients With COVID-19: Validation Study.

Background

The COVID-19 pandemic has affected the response capacity of the health care workforce, and health care professionals have been experiencing acute stress reactions since the beginning of the pandemic. In Spain, the first wave was particularly severe among the population and health ...
S-EPMC7945973 | biostudies-literature
UnknownImmunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial.

Background

To date, no immunological data on COVID-19 heterologous vaccination schedules in humans have been reported. We assessed the immunogenicity and reactogenicity of BNT162b2 (Comirnaty, BioNTech, Mainz, Germany) administered as second dose in participants primed with ChAdOx1-S (Vaxzev...
S-EPMC8233007 | biostudies-literature
UnknownAssociation between parental socioeconomic status with underweight and obesity in children from two Spanish birth cohorts: a changing relationship.

Background

Our objective was twofold: to estimate the prevalence of underweight, overweight, and obesity in two birth cohorts (1999-2000 and 2007-2008) from Castilla-La Mancha, Spain; and to examine the association between parental socioeconomic status (SES) and weight status in these two co...
S-EPMC4687138 | biostudies-literature
UnknownRationale and methods of a randomised cross-over cluster trial to assess the effectiveness of MOVI-KIDS on preventing obesity in pre-schoolers.

Background

Childhood obesity has become an alarming worldwide increasing public health problem. The earlier adiposity rebound occurs, the greater the risk of becoming obese during puberty and adolescence. It has been speculated about the potential influence of vigorous physical activity on m...
S-EPMC4350633 | biostudies-literature
UnknownSymptomatic subsegmental versus more central pulmonary embolism: Clinical outcomes during anticoagulation.

Background

The optimal therapy of patients with acute subsegmental pulmonary embolism (PE) is controversial.

Methods

We used the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the rate of symptomatic PE recurrences during anticoagulation in patients with ...
S-EPMC7845079 | biostudies-literature
UnknownEffectiveness of an intensive E-mail based intervention in smoking cessation (TABATIC study): study protocol for a randomized controlled trial.

Background

Intensive interventions on smoking cessation increase abstinence rates. However, few electronic mail (E-mail) based intensive interventions have been tested in smokers and none in primary care (PC) setting. The aim of the present study is to evaluate the effectiveness of an intens...
S-EPMC3648415 | biostudies-literature
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