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TranscriptomicsArabidopsis thaliana gene expression upon exposure to nanoparticles (NPs), biotic and abiotic stresses, or NPs plus ABA phytohormone, PART 1
Here we provide a set of 16 comparable transcriptome measures to monitor early changes in gene expression upon NP exposure. We evaluated A. thaliana response to 8 different types of NPs (metallic, carbonaceous and ranging from 10 to 80 nm) in comparison to biotic and abiotic stress inducers that rep...
ORGANISM(S): Arabidopsis thaliana 
2015-04-29 | E-MTAB-3331 | biostudies-arrayexpress
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
ProteomicsQuantitative Proteomic Study Unmasks Fibrinogen Pathway in Polycystic Liver Disease
(1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism is currently unknown and the PLD treatment is limited to liver transplantat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031253 | Pride
Pld  swath  quantitative proteomics  therapeutic targets 
ProteomicsPIAS2b dsRNAi repression kills by mitotic catastrophe anaplastic thyroid and non-thyroid carcinomas, but not normal thyroid or differentiated carcinomas
The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an undifferentiated cancer with very high mortality. Double-stranded RNA–directed RNA interference (dsRNAi) targeting the PIAS2 isoform beta (...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD044110 | Pride
Sumo-affinity columna Pias2 Anaplastic thyroid cancer Immunoprecipitation E3 sumo ligase 
ProteomicsA comparative proteomic, transcriptomic and glycomic analysis of extracellular vesicle isolation techniques highlights ExoGAG efficiency for a more complete identification of breast milk molecular signaling pathways
Background: Human milk (HM) is the earliest form of extrauterine communication between mother and infant. We recently showed a functional characterization of HM, unmasking the molecular mechanisms related to EV signaling and its functional role in prematurity. In that study, we identified the need t...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD060683 | Pride
Glycomics. Proteomics Extracellular vesicles Human milk Transcriptomics Isolation method 
ProteomicsTreatment choice matters in multiple sclerosis: The role of extracellular vesicles in predicting treatment response.
Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend thedisease’s pathogenesis iscrucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles s...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD038003 | Pride
Rheumatoid arthritis  subcortical stroke.icles Blood  exosomes  extracellular vesicles  multiple sclerosis  proteomic analysis Extracellular vesbiomarkers Intracerebral hemorrhage Rat Proteomics Blood 
UnknownDetection of balance in the elderly under the influence of stress (DEPIE): A cross-sectional study protocol.
Not available
S-EPMC12843555 | biostudies-literature
TranscriptomicsOverexpression of non-degradable SAS-6 KEN box mutant in RPE-1 cells
Stable clones of RPE-1 cells expressing tetracycline-inducible wild type SAS-6 or SAS-6ND were obtained via lentiviral gene transduction with the pLVX tet-on Advanced inducible gene expression system (Clontech). Stable expressors were derived by selection with 5 μg/mL puromycin (Sigma-Aldrich, UK). ...
ORGANISM(S): Homo sapiens 
2025-01-27 | E-MTAB-13783 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in macrophages stimulated 18 h with Adiponectin
Bone marrow derived macrophages (BMDM) generated from c57bl/6j mice bone marrow cells were stimulated for 18 h with 12 microgram/ml adiponectin, RNA from non-stimulated or 18 h adiponectin-stimulated BMDM subjected to a agilent microarray analysis Three different non-stimulated and 3 different 1...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-49332 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of SAGA, TREX2 and Sem1
Evidence indicates that transcription and mRNA export are linked processes. The molecular mechanisms of this coordination are not clear however. Sus1 (hENY2) participates in this coordination as part of two protein complexes: SAGA, a transcriptional co-activator and TREX-2 that functions in mRNA bio...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-04 | E-GEOD-39861 | biostudies-arrayexpress
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