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UnknownPIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
Not available
S-EPMC8758491 | biostudies-literature
UnknownProtein inhibitor of activated STAT 2 (PIAS2) protects against podocyte injury in diabetic nephropathy via inhibiting JAK2/STAT3 pathway.
Not available
S-EPMC12680398 | biostudies-literature
UnknownDuck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity.
Not available
S-EPMC7300270 | biostudies-literature
ProteomicsPIAS2b dsRNAi repression kills by mitotic catastrophe anaplastic thyroid and non-thyroid carcinomas, but not normal thyroid or differentiated carcinomas
The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an undifferentiated cancer with very high mortality. Double-stranded RNA–directed RNA interference (dsRNAi) targeting the PIAS2 isoform beta (...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD044110 | Pride
Sumo-affinity columna Pias2 Anaplastic thyroid cancer Immunoprecipitation E3 sumo ligase 
UnknownSUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
Not available
S-EPMC7212658 | biostudies-literature
Transcriptomics17b-Trenbolone study
We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 day) exposure to 0.1 or 1.0 µg/L of, 17β-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in ...
ORGANISM(S): Pimephales promelas 
2010-05-14 | E-GEOD-12904 | biostudies-arrayexpress
UnknownProtein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation.
Not available
S-EPMC5691636 | biostudies-literature
TranscriptomicsMiz1 is required to maintain physiological levels of autophagic flux_1
Mice: knock-out of the Miz1 POZ-domain in brain (Miz1DPOZNes) and control mice. The RNA expression in cerebella of of old Miz1 delta POZ mice (1.5 years), old control mice (1.5 years), young Miz1 delta POZ mice (5.5 weeks) and young control mice (5.5 weeks) was compared
ORGANISM(S): Mus musculus 
2013-10-01 | E-MEXP-3878 | biostudies-arrayexpress
TranscriptomicsA Zebrafish JAK1-A634D Gain-of-Function Model Provides New Insights into the Pathogenesis of Familial Hypereosinophilia
JAK1 plays an important role during zebrafish development as hematopoietic regulator with a specific impact in the myeloid lineage, from where the eosinophils arise. Several genes in the JAK-STAT pathway are elevated in the transgenic mutants (STAT1B, SOCS3A, SOCS3B, PIAS2) as well as patways involv...
ORGANISM(S): Danio rerio 
2019-12-27 | GSE142599 | GEO
UnknownMulti-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability.
Not available
S-EPMC12748365 | biostudies-literature
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