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ProteomicsDevelopment of a 3D fatty infiltration platform to model, at higher scale, the impact of LY2090314 compound on fibro/adipogenic progenitor adipogenic drift
In human dystrophies, the progressive muscle wasting is exacerbated by ectopic deposition of fat and fibrous tissue originating from fibro/adipogenic progenitors (FAPs). In degenerating muscles, the ability of these cells to adjuvate a successful healing is attenuated and FAPs aberrantly expand and ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD040479 | Pride
Ly2090314 Faps Duchenne muscular dystrophy Adipogenesis B-catenin 
Proteomics3D bioprinting directly affects proteomic signature and myogenic maturation in muscle pericytes-derived human myo-substitute
Skeletal muscle tissue engineering (SMTE) has recently emerged to address major clinical challenges such as volumetric muscle loss. Here, we report a rotary wet-spinning (RoWS) biofabrication technique for producing human myo-substitutes with biomimetic architectures and functions. Here, we demonstr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD043605 | Pride
Myogenic maturation Myosubstitute Bioprinting Perycites 
TranscriptomicsRNA-seq comparison of fibro-adipogenic progenitors (FAPs) from wild type, mdx and cardiotoxin-injured mice
We purified FAPs from the hind limbs of wild type, mdx and cardiotoxin-injured mice in order to unveil changes in their transcriptomes. RNA was isolated directly from sorted cells and analyzed by 3’ RNA sequencing.
ORGANISM(S): Mus musculus 
2019-06-20 | E-MTAB-8040 | biostudies-arrayexpress
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