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ProteomicsDevelopment of a 3D fatty infiltration platform to model, at higher scale, the impact of LY2090314 compound on fibro/adipogenic progenitor adipogenic drift
In human dystrophies, the progressive muscle wasting is exacerbated by ectopic deposition of fat and fibrous tissue originating from fibro/adipogenic progenitors (FAPs). In degenerating muscles, the ability of these cells to adjuvate a successful healing is attenuated and FAPs aberrantly expand and ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD040479 | Pride
Ly2090314 Faps Duchenne muscular dystrophy Adipogenesis B-catenin 
UnknownActivating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Not available
S-EPMC4411090 | biostudies-literature
TranscriptomicsWnt/β-catenin signaling activation induces differentiation in human limbal epithelial stem cells cultured ex vivo
hLESC ex vivo cultures treated with GSK-3 inhibitor LY2090314 (small molecule) to activate Wnt/β-catenin signaling and further examine the impact of canonical Wnt/β-catenin signaling activation on hLESCs. We used microarray to explore the changes in gene expression in GSK-3 inhibitor LY2090314 treat...
ORGANISM(S): Homo sapiens 
2023-06-26 | GSE234403 | GEO
TranscriptomicsStructural and Functional Characterization of TgGSK3, a Druggable Kinase in Toxoplasma gondii
Toxoplasma gondii and Cryptosporidium species are apicomplexan parasites of significant medical and veterinary importance. Although current therapeutic options for toxoplasmosis and cryptosporidiosis demonstrate notable efficacy, their clinical efficacy is often limited by suboptimal efficacy and fr...
ORGANISM(S): Toxoplasma gondii 
2025-01-20 | GSE286338 | GEO
UnknownA 3D adipogenesis platform to study the fate of fibro/adipogenic progenitors in muscular dystrophies.
Not available
S-EPMC10309591 | biostudies-literature
UnknownStructural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii.
Not available
S-EPMC12589562 | biostudies-literature
UnknownBioinformatics-based screening and prediction of compounds and antigen epitopes for immune targets with point mutations in colitis-associated colorectal cancer.
Not available
S-EPMC12858706 | biostudies-literature
UnknownInsilico targeting of virus entry facilitator NRP1 to block SARS-CoV2 entry.
Not available
S-EPMC11798527 | biostudies-literature
TranscriptomicsRNA-seq transcriptional profiling in the Fah-/- livers after transplantation and YC treatment
The transplanted mature hepatocytes were found to dedifferentiate into hepatic progenitor cells (HPCs), which proliferate and then convert back to mature state at the completion of liver repopulation. The combination of two small molecules Y-27632 (Y, Rock inhibitor) and CHIR99021 (C, Wnt agonist) c...
ORGANISM(S): Mus musculus 
2022-12-17 | GSE218952 | GEO
UnknownSynthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts.
Not available
S-EPMC11011321 | biostudies-literature
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