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ProteomicsDNA Damage in Macrophages Drives Immune Autoreactivity via Nuclear Antigen Presentation
Aging and DNA damage increase the risk of chronic inflammation and autoimmunity, yet their molecular underpinnings remain unclear. Here, we uncover a DNA damage-driven mechanism in macrophages that triggers immune autoreactivity. Using Er1Lyz2/- animals with a macrophage-specific DNA repair defect i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-02 | PXD058775 | Pride
Dna damage  immunosenescence  antigen presentation  autophagy  immunopeptidomics  autoimmune responses  t-cell responses 
ProteomicsERCC1-XPF Cooperates with CTCF and the Cohesin to Facilitate the Developmental Silencing of Imprinted Genes
Inborn defects in DNA repairare associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD005897 | Pride
Levers Ap-ms In vivo biotinylation tagging Mouse Ner Label-free Ercc1-xpf 
TranscriptomicsTranscription profiling by array of Taf10 KO livers
Transcriptional profiling of Taf10-/- livers as compared to age-matched wild_type controls.
ORGANISM(S): Mus musculus 
2012-03-15 | E-MEXP-3442 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Gata3 conditional knock out mice to investigate epidermis and hair follicle differentiation
Transcriptome analysis on Gata3 conditional knock out murine hair follicles. Background. The transcription factor Gata3 is critically involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, which processes ar...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-634 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type or Ercc1 mutant mice
The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To ...
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and DNA repair-deficient primary dermal fibroblasts upon exposure to ultraviolet irradiation
Transcription profiling of wild type and DNA repair-deficient cells upon exposure to ultraviolet irradiation.
ORGANISM(S): Mus musculus 
2009-04-01 | E-MEXP-1968 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dermal fibroblasts exposed to hydrogen peroxide
Mouse dermal fibroblasts exposed to 0, 10 and 50mM of Hydrogen peroxide
ORGANISM(S): Mus musculus 
2009-03-01 | E-MEXP-1975 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of NER progeroid animals treated with an NF-kB inhibitor.
NBD treatment of animals: Sibling pairs of Ercc1-/delta mice housed in a single cage were treated with 8K-NBD or 8K-mNBD 10 mg/kg three times per week intraperitoneally by an investigator blinded as to the treatment group. Treatment began at 5 weeks of age before the animals were symptomatic and con...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MEXP-3615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Ercc1-/- mice and wild type littermates to investigate features of premature aging
To investigate the cause of the premature aging features in the Ercc1-/- mouse, we compared the entire transcriptome of the Ercc1-/- mouse liver to that of wildtype littermates at the age of 15 days, when the Ercc1-/- mice reached their maximal weight and had symptoms of progeria, yet overall pathol...
ORGANISM(S): Mus musculus 
2006-12-21 | E-MEXP-834 | biostudies-arrayexpress
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