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ProteomicsDNA Damage in Macrophages Drives Immune Autoreactivity via Nuclear Antigen Presentation
Aging and DNA damage increase the risk of chronic inflammation and autoimmunity, yet their molecular underpinnings remain unclear. Here, we uncover a DNA damage-driven mechanism in macrophages that triggers immune autoreactivity. Using Er1Lyz2/- animals with a macrophage-specific DNA repair defect i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-02 | PXD058775 | Pride
Dna damage  immunosenescence  antigen presentation  autophagy  immunopeptidomics  autoimmune responses  t-cell responses 
ProteomicsERCC1-XPF Cooperates with CTCF and the Cohesin to Facilitate the Developmental Silencing of Imprinted Genes
Inborn defects in DNA repairare associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD005897 | Pride
Levers Ap-ms In vivo biotinylation tagging Mouse Ner Label-free Ercc1-xpf 
TranscriptomicsNotch targets stem-cell and temporal-programming genes to orchestrate neuroblast tumours
Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyper-activatio...
ORGANISM(S): Drosophila melanogaster 
2016-10-18 | E-MTAB-3561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type mice of different ages to determine whether gene expression changes in naturally aged mice overlap with those from DNA repair deficient mice
To investigate whether and to which extent the gene expression changes in DNA repair deficient mice (i.e. Csbm/m/Xpa-/- and Ercc1-/-) overlap with those observed in a natural aged liver, we sought to compare the full mouse liver transcriptome of adult 16-, 96- and 130-week old wt C57Bl/6J mice (n=4)...
ORGANISM(S): Mus musculus 
2006-12-21 | E-MEXP-839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Ercc1 white adipose tissue
Transcriptome analysis of epididymal white adipose tissue (WAT) depots in Ercc1 animals: To further elucidate the role of ERCC1 in WAT we scanned the transcriptome of 15 day old wt and Ercc1 epididymal WAT.
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3930 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse dermal fibroblasts upon UV irradiation in a time-, dose- and lesion-dependent manner
Each labeled cDNA sample constituted a unique combination of UV dose (2J, 4J or 8J), time point (-30min, 0h, 2h, 4h, 8h and 24h) and photoreactivation status (PR or non-PR) that defined a distinctive matrix point. All samples were hybridized to non-irradiated, non-photoreactivated MDFs of the pertin...
ORGANISM(S): Mus musculus 
2004-09-01 | E-MEXP-117 | biostudies-arrayexpress
TranscriptomicsXAB2 binds genome-wide on putative DNA elements (e.g. enhancers, promoters) that are known to regulate gene expression
XAB2 ChIP-Seq profile of mESCs treated with trans-retinoic acid (tRA), a pleiotropic factor known to activate transcription and regulate gene expression during cell differentiation and embryonic development and CHIP-Seq profile of the same cells untreated.
ORGANISM(S): Mus musculus 
2020-08-19 | E-MTAB-8033 | biostudies-arrayexpress
GenomicsThe role of DNA repair endonuclease XPF in transcription
In this experiment we want to explore and compare the bindind of XPF in normal MEFs, in tRA treated MEFs and in UV radiated MEFs
ORGANISM(S): Mus musculus 
2020-08-19 | E-MTAB-8154 | biostudies-arrayexpress
TranscriptomicsAge- and Obesity Induced Decline of Brown Fat Function as Consequence of Impaired miR-328 Dependent Silencing of Bace1
Activated brown adipose tissue contributes to control of energy and glucose homeostasis in rodents and humans. Defining cell-autonomous processes underlying BAT differentiation and activation may thus reveal novel therapeutic targets for obesity and type 2 diabetes mellitus intervention. Here we sho...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-69913 | biostudies-arrayexpress
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