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ProteomicsDevelopmet and Characterization of Three Cell Culture Ststems to Investigate the Relationship Between Primary Bone Marrow Adipocytes and Myeloma Cells
The unique properties of the bone marrow allow for migration and proliferation of multipl myeloma (MM) cells, while also providing the perfect environment for development of quiescent, drug-resistant MM cell clones. Bone marrow adipocytes (BMAds), which have recently been identified as important con...
ORGANISM(S): Homo sapiens (Human) 
2023-01-04 | PXD032753 | Pride
3d Tissue engineering Adipocytes Silk scaffolds Myeloma Bone marrow adipose 
ProteomicsInhibition of Acyl-CoA Synthetase Long Chain (ACSL) Isozymes Decreases Multiple Myeloma Cell Proliferation, Mitochondrial Function and Affects Key Survival Pathways
Multiple myeloma (MM) is an incurable cancer of plasma cells that will cause ~12,590 deaths in the USA in 2023. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression but the underlying mechanisms remain unknown. The acyl-CoA synthetase long-chain family member...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD049304 | Pride
Triacsin c Acsl Multiple myeloma Mm.1s Acyl-coa synthetase long chain Fatty acid metabolism 
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Background

Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease.

Methods

We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's d...
S-EPMC4159618 | biostudies-literature
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