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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
TranscriptomicsTranscription profiling of human skeletal muscle from morbidly obese patients before and after gastric bypass surgery to identify genes responsive to weight loss.
Obesity results from a chronic imbalance between energy intake and energy expenditure, with excess calories stored as fat. As such, weight loss has long been considered as a primary goal of treatment for obesity. A surgical treatment of severe obesity such as gastric bypass provides the most dramati...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5109 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss
Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this wo...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats subjected to Roux-en-Y gastruc bypass to characterize of weight loss and weight regain mechanisms
Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a ~20% failure rate. We used our established RYGB model in diet-induced obese (DIO) Sprague-Dawley rats, which reproduces human bi-phasic body weight (BW) loss pattern, to determine mechanisms contributing t...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8314 | biostudies-arrayexpress
TranscriptomicsExpression data from open bariatric surgery patients - various adipose samples
Diabetes and obesity are widespread diseases with signifciant socioeconomic implications. We used three different types of human adipose tissue (epigastric, visceral, and subcutaneous) in order to determine differences in global gene expression between these adipose depots in severely obese patient...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-42715 | biostudies-arrayexpress
ProteomicsFecal Transplant from Roux-Y-Gastric-Bypass rat model into a diet induced obesity rat model
Investigating alterations the intestinal microbiome in a diet induced obesity (DIO) rat model after fecal transplant from rats, which underwent Roux-Y-Gastric-Bypass surgery (RYGB). The microbiomes of the RYGB-donor rats, the DIO rats, and DIO rats after receiving the fecal transplant from the RYGB ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD026606 | Pride
Roux-y-gastric bypass surgery Metaproteomics Microbiome Obesity Rat Anti-biotics 
TranscriptomicsTranscription profiling of human adipose tissue using an expanded patient cohort
Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expre...
ORGANISM(S): Homo sapiens 
2010-04-07 | E-GEOD-20950 | biostudies-arrayexpress
GenomicsGastric Bypass and the Microbiome
Gastric Bypass and the Microbiome
PRJEB50752 | ENA
ProteomicsNovel insights on remnant stomach following Roux-en-Y Gastric Bypass surgery based on histological evaluation and quantitative proteomics analysis
Background: Patients undergoing weight-reducing Roux-en-Y gastric bypass (RYGB) have immediate positive effects on metabolic health, including type 2 diabetes (T2D). Refeeding via the secluded stomach, either by a gastrotube or after gastro-gastric fistulation result in T2D relapse and weight regain...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD065508 | Pride
Human  proteomic remnant stomach  roux-en-y gastric bypass 
ProteomicsSystems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery
Gastric bypass surgery (GBP) emerging as a powerful tool for treatment of obesity has been applied for remission of diabetes. However, the GBP global molecular effects on diabetes remission independent of weight loss remain largely unknown. We profiled plasma metabolites and proteins of 10 normoglyc...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD008071 | Pride
Network Gastric bypass Diabetes Systems signature 
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