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ProteomicsArchitecture of the human KICSTOR and GATOR1-KICSTOR complexes
Our understanding of the molecular processes by which cells sense nutrients has seen rapid progress, largely due to new structural andfunctional insights into the mTORC1 pathway. Serving as a key regulator of cellular growth, mTORC1 coordinates various environmental signalssuch as growth factors, nu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-20 | PXD060391 | Pride
Kicstor X-link Gator1 
GenomicsGATOR1 complex controls cellular cisplatin accumulation and sensitivity in cancer
GATOR1 complex controls cisplatin sensitivity
PRJEB98686 | ENA
GenomicsGATOR1 complex controls cellular cisplatin accumulation and sensitivity in cancer
GATOR1 complex controls cisplatin sensitivity
PRJEB98685 | ENA
UnknownArchitecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Not available
S-EPMC5975964 | biostudies-literature
UnknownGATOR1 complex controls cisplatin sensitivity.
Not available
S-EPMC12824275 | biostudies-literature
UnknownThe landscape of epilepsy-related GATOR1 variants.
Not available
S-EPMC6292495 | biostudies-literature
TranscriptomicsGenome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis
Identifying tumor suppressor genes is predicted to inform on the development of novel strategies for cancer therapy. To identify new lymphoma driving processes that cooperate with oncogenic MYC (which is abnormally highly expressed in ~70% of human cancers) we have used a genome-wide CRISPR knockout...
ORGANISM(S): Mus musculus 
2025-07-23 | GSE285351 | GEO
GenomicsGenome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis
Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis
PRJNA1203216 | ENA
UnknownGATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Not available
S-EPMC10889792 | biostudies-literature
UnknownSrc regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction.
Not available
S-EPMC6195609 | biostudies-literature
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