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ProteomicsArchitecture of the human KICSTOR and GATOR1-KICSTOR complexes
Our understanding of the molecular processes by which cells sense nutrients has seen rapid progress, largely due to new structural andfunctional insights into the mTORC1 pathway. Serving as a key regulator of cellular growth, mTORC1 coordinates various environmental signalssuch as growth factors, nu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-20 | PXD060391 | Pride
Kicstor X-link Gator1 
ProteomicsProteomics analysis unravels new functions of the KICSTOR component SZT2
Developmental and epileptic encephalopathy is a group of rare, severe neurodevelopmental disorders characterized by the co-occurrence of epilepsy and intellectual disability (ID), in which there is additional developmental impairment independent of epileptic activity. In 2009, through a chemical mut...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027662 | Pride
Szt2 Lysosome Mtorc1 Kicstor 
UnknownKICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Not available
S-EPMC5360989 | biostudies-literature
UnknownBi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy.
Not available
S-EPMC11866974 | biostudies-literature
UnknownThe SZT2 Interactome Unravels New Functions of the KICSTOR Complex.
Not available
S-EPMC8534408 | biostudies-literature
UnknownVWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes.
Not available
S-EPMC10733324 | biostudies-literature
UnknownMolecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling.
Not available
S-EPMC10883374 | biostudies-literature
UnknownFBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth.
Not available
S-EPMC12904710 | biostudies-literature
UnknownRag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.
Not available
S-EPMC11363303 | biostudies-literature
UnknownUncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers.
Not available
S-EPMC11804928 | biostudies-literature
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