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TranscriptomicsExpression profiling of 40 NSCLC cell lines
INTRODUCTION: CDKN2A (p16) inactivation is common in lung cancer and occurs via homozygous deletions, methylation of promoter region, or point mutations. Although p16 promoter methylation has been linked to KRAS mutation and smoking, the associations between p16 inactivation mechanisms and other com...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-63882 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for Ovarian Cancer Samples
This study aimed to generate a new panel of comprehensively, genomically characterized high-grade serous ovarian carcinoma (HGSOC) cell line and xenograft models. Multidimensional genomic data were generated and compared between cell lines/xenografts and the tumours they were derived from, indicatin...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-71522 | biostudies-arrayexpress
TranscriptomicsIllumina HumanMethylation450 array data for Ovarian Cancer Samples
This study aimed to generate a new panel of comprehensively, genomically characterized high-grade serous ovarian carcinoma (HGSOC) cell line and xenograft models. Multidimensional genomic data were generated and compared between cell lines/xenografts and the tumours they were derived from, indicatin...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-71523 | biostudies-arrayexpress
TranscriptomicsIllumina HT-12 v4 expression array data for Ovarian Cancer Samples
This study aimed to generate a new panel of comprehensively, genomically characterized high-grade serous ovarian carcinoma (HGSOC) cell line and xenograft models. Multidimensional genomic data were generated and compared between cell lines/xenografts and the tumours they were derived from, indicatin...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-71524 | biostudies-arrayexpress
UnknownGene expression analysis of lung adenocarcinoma and matched adjacent non-tumor lung tissue
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-32863 | biostudies-other
TranscriptomicsGene expression analysis of lung adenocarcinoma and matched adjacent non-tumor lung tissue
Gene expression profiling of 60 lung adenocarcinoma tumors and their matched histologically normal adjacent lung tissue samples were analyzed using Illumina HumanWG-6 v3.0 expression beadchip. We integrated these data with DNA methylation profiles of the same samples to identify potential DNA methyl...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-32863 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 83 matched pairs of lung adenocarcinomas and non-malignant adjacent tissue
Background: Non-small cell lung cancers (NSCLCs) consist of adenocarcinoma (ADC), squamous cell carcinoma (SCC) and other types. Since most NSCLCs are now diagnosed from small biopsies or cytology materials, classification is not always accurate. This is a problem as many therapy regimens and clinic...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-75037 | biostudies-arrayexpress
GenomicsA small cell lung cancer genome reports complex tobacco exposure signatures
Cancer is driven by mutation. Worldwide, tobacco smoking is the major lifestyle exposure that causes cancer, exerting carcinogenicity through 60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small cell lung cancer cell line, NCI-H209, to explore t...
EGAS00000000051 | EGA
TranscriptomicsMicrotubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-57966 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung cancer cells treated with 5-aza - a genome-wide screen for hypermethylated genes in lung cancer
Abstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are init...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5816 | biostudies-arrayexpress
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