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MetabolomicsGenetically defined human GBM organoids reveal principles of GBM development and actionable targets
Not available
ORGANISM(S): Homo sapiens 
ST002284 | MetabolomicsWorkbench
MetabolomicsGBM Cell Lines Reproducibility Pilot Study
Not available
ORGANISM(S): Homo sapiens 
ST000301 | MetabolomicsWorkbench
TranscriptomicsIdentification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)
Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an or...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-16805 | biostudies-arrayexpress
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
ProteomicsExosomes from GBM established cell lines (U87, U373) and GBM primary CSC
In this study, we investigated and compared the miRNA and protein content of the small EVs released by different human GBM established cell lines and by GBM primary CSC lines, to explore the role of EVs in their different tumor behavior and capacities.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-11 | MSV000088671 | MassIVE
TranscriptomicsNAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
The aim of this study is to determine if, using antioxidant drugs, it is possible to interfere with the proliferative capabilities of the human glioblastoma (GBM) tumor-initiating cells (TICs). To establish which cellular processes are activated in GBM TICs by the antioxidants NAC, Tiron and Trolox,...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44099 | biostudies-arrayexpress
ProteomicsReverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
To determine the biological effects of MPS1 inhibition (both by siRNA and Drug (NMSP715)) on signaling pathways in GBM cells (U251 &U87), we profiled the modulation of phosphorylated and non-phosphorylated proteins using RPPA Relative protein levels for each sample were determined by interpolation o...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-67502 | biostudies-arrayexpress
ProteomicsGBM cell line secretome analysis
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose of the present study was to identify GBM cell-selective secreted proteins by analyzing conditioned media (CM) from GBM, breast, and colon cancer cell lines using sequential window acquisition of all theoretical s...
ORGANISM(S): Homo Sapiens (human) 
2020-09-19 | PXD016898 | JPOST Repository
TranscriptomicsGBM brain tumors
This SuperSeries is composed of the following subset Series: GSE24446: Genetic abnormalities in GBM brain tumors GSE24452: Genetic abnormalities in various cell subpopulations of GBM brain tumors GSE24557: Exon-level expression profiles of GBM brain tumors Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-11-21 | E-GEOD-24558 | biostudies-arrayexpress
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