Hypoxia frequently occurs during rapid tumour growth. However, how tumour cells adapt to hypoxic stress by remodeling central cellular pathways remains largely unclear. Here, we demonstrated that hypoxia induces casein kinase 2 (CK2)-mediated glucokinase (GCK) S398 phosphorylation, which exposes its...
A comprehensive glucokinase (GCK) single amino acid substitution library was used in a reverse two-hybrid assay to examine the interaction of GCK variants with glucokinase regulatory protein (GKRP).
