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UnknownDCLK1 Drives EGFR-TKI-Acquired Resistance in Lung Adenocarcinoma by Remodeling the Epithelial-Mesenchymal Transition Status.
Not available
S-EPMC10216632 | biostudies-literature
MetabolomicsGut microbial release of ferulic acid from germinated quinoa alleviates obesity-associated cognitive impairment via activation of PINK1/Parkin-mediated mitophagy in the hippocampus

Background Obesity is a major risk factor for cognitive impairment and related neurodegenerative disorders. Whole grains are rich in polyphenols and dietary fiber, and their consumption has been associated with improvements in obesity and cognitive deficits. Gut microbial genes encode enzymes tha...

2026-03-30 | MTBLS14185 | MetaboLights
ProteomicsDiscovery of peptide biomarkers in male Eupolyphaga sinensis Walker (Tubiechong) by dimethyl labeling-based quantitative peptidomics analysis
Eupolyphaga sinensis Walker is a traditional Chinese medicinal insect. However, the peptide composition differences between male and female ES, which may underlie their distinct medicinal efficacies, remain largely unexplored. In this study, we performed a quantitative peptidomics analysis using sta...
ORGANISM(S): Eupolyphaga sinensis 
2026-09-07 | PXD080333 | Pride
Eupolyphaga sinensis peptide biomarkers dimethyl labeling Lc-ms/ms 
ProteomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
PTEN, a widely investigated tumor suppressor, has at least two longer translational variants, PTEN and . However, the regulation and precise roles of endogenous PTEN/ in tumorigenesis remain greatly unknown. Here we show that USP9X and FBXW11 selectively regulate the stability of PTEN/ but not PTEN ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD013196 | Pride
Ptena  ptenb  pten  usp9x  fbxw11  ubiquitination wdr5  carcinogenesis 
UnknownRestoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia.
Not available
S-EPMC7449869 | biostudies-literature
ProteomicsImmunoprecipitation of PTEN coupled Nano-LC−ESI-MS/MS
Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017983 | Pride
Immunoprecipitation Pten Nano-lc−esi-ms/ms 293t 
ProteomicsThe The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-induced CytotoxicitySecretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-induced Cytotoxicity
Breast cancer remains one of the leading causes of death in women, being the chemotherapeutic agent doxorubicin (Dox) among the most widely standard chemotherapy options for its treatment. However, its effective use has been severely limited owing to its well-documented cardiotoxic side effect that ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025633 | Pride
Human  breast cancer  proteome  mesenchymal stem/stromal cells  secretome  3d cultures 
UnknownArsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells.
Not available
S-EPMC6902349 | biostudies-literature
UnknownA T-cell independent universal cellular therapy strategy through antigen depletion.
Not available
S-EPMC8771543 | biostudies-literature
UnknownMLL is required for miRNA-mediated translational repression.
Not available
S-EPMC6796902 | biostudies-literature
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