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We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
We conducted unbiased mass spectrometric experiments to evaluate the specificity of NCL-ZATAC#20. In these studies, HEK293T cells expressing GFP-NCL were treated with NCL-ZATAC#20. The result revealed the detection of more than 6000 proteins, among which there was a notable degradation of GFP-NCL, c...
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD060634 | Pride
A variety of newly developed next-generation sequencing technologies are making their way rapidly into the research and clinical applications, for which accuracy and cross-lab reproducibility are critical, and reference standards are much needed. However, there is still a lack of well-characterized ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD052353 | Pride

BACKGROUND: Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are current clinical challenges.

METHODS: The serum metabolites of 20 healthy individuals and patients with prostat...

2023-04-17 | MTBLS6038 | MetaboLights
Introducing a clinical-practical, alternative splicing activity-based proteogenomic method that identifies, in their oncogenically active states, biomarker genes bearing patient-specific GE or copy-number alterations of prognostic significance. This integrated multi-omics method uses intronic splici...
ORGANISM(S): Homo sapiens (Human) 
2018-03-20 | PXD008642 | Pride
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