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TranscriptomicsGene expression profile of decidual macrophages and different in vitro M1 and M2 macrophage populations
Uterine (decidual) macrophages (M) are believed to play an important role in fetal tolerance during pregnancy, but the factors that regulate them are not known. In this study we investigated the potential role of several factors (M-CSF, GM-CSF, IL-4/13, IL-10, progesterone and estradiol) to drive th...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30595 | biostudies-arrayexpress
TranscriptomicsExpression profiling of HCC
61 human HCCs were analyzed for genome-wide gene expression. Samples were collected at two sites in Germany, Heidelberg (HD) and Hannover (N). The Heidelberg Collection include 40 independent HCC: 19 liver resections and 17 explant liver specimen (4 not determined); median age at surgery was 57 year...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50579 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages in response to infection with Streptococcus pyogenes
The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression using a high-density oligomer microarray. More than 400 genes were identified as being differentially regulated. Many of the up-regulated genes encoded molecules were ...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-7769 | biostudies-arrayexpress
TranscriptomicsPax6 mutant neocortex vs. wild type
Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32271 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human decidual macrophages
Uterine macrophages are thought to play an important regulatory role at the maternal-fetal interface. We report here a unique gene expression pattern intrinsic of first trimester decidual monocytes/macrophages, but not of their blood counterparts. The micro-array data comprises approximately 14,000 ...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-10612 | biostudies-arrayexpress
TranscriptomicsCAL-51 breast cancer side population cells
Human solid tumors contain rare cancer side population (SP) cells, which expel the fluorescencent dye H33342 and display cancer stem cell characteristics. Transcriptional profiling of cancer SP cells isolated by H33342 fluorescence analysis is a newly emerging approach to discover cancer stem cell m...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-18773 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression during the development of experimental biliary atresia in different mouse strains
Biliary atresia (BA) is a rare cholestatic disease of unknown etiology that affects infants and shows an incidence of 1 out of 18,000 live births in Europe (1). The first therapeutic option is a timely performed portoenterostomy. However, the majority of patients suffer from a progressive inflammato...
ORGANISM(S): Mus musculus 
2009-08-30 | E-GEOD-13245 | biostudies-arrayexpress
TranscriptomicsMast cells in response to some pathogens elicit a transcriptional program devoid of type I IFN response
Although mast cells elicit proinflammatory and type I IFN responses upon VSV infection, in response to L.monocytogenes (L.m) or S. Typhimurium (S.t), such cells elicit a transcriptional program devoid of type I IFN response. Balanced induction of proinflamatory and type I interferon (IFN) response...
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-18500 | biostudies-arrayexpress
TranscriptomicsProfiling of p53-responsive genes in human breast cancer cells harboring endogenous ts-p53 E285K
The ts-p53 E285K protein is a rare p53 mutant with temperature-sensitive (ts) loss of function characteristics. In cancer cells, which express ts-p53 E285K intrinsically, endogenous wild type p53 activity is reconstituted by appropriate cultivation temperature (permissive condition). At non-appropri...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of macrophages derived from WT and Vdr dificient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3 to study molecular mechanisms of macrophage activation
Gene expression profiling of macrophages derived from WT and Vdr deficient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2421 | biostudies-arrayexpress
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