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GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post mortem spinal cord grey matter from sporadic and familial ALS patients vs controls to identify amyotrophic lateral sclerosis (ALS) associated genes
Identification of amyotrophic lateral sclerosis (ALS) associated genes. Post mortem spinal cord grey matter from sporadic and familial ALS patients compared with controls.
ORGANISM(S): Homo sapiens 
2007-09-26 | E-GEOD-833 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of C9ORF72 ALS fibroblast
The purpose of this experiment was to compare the differences in transcript levels between RNA samples collected from fibroblasts from healthy control patients, amyotrophic lateral sclerosis (ALS) patients carrying an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene and...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1926 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of post-mortem brain cortex from healthy control patients and amyotrophic lateral sclerosis patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 (C9ORF72) gene
The purpose of this experiment was to compare differences in the transcript level between RNA samples collected from post-mortem motor cortex from healthy control patients and amyotrophic lateral sclerosis (ALS) patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading ...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1925 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in fast and slow skeletal muscle of wild type and SOD1-G93A mice
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. In a mouse model of ALS that expresses mutated human superoxide dismutase 1 (SOD1-G93A) skeletal muscle is one of the tissues affected early by m...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55507 | biostudies-arrayexpress
TranscriptomicsAmyotrophic lateral sclerosis: SOD1 mouse model
Identification of familial amyotrophic lateral sclerosis (fALS) related genes. Material from three hSOD1(G93A) transgenic mice was compared to material from three non-transgenic control mice using an alternating loop design on two-colour cDNA microarrays. Statistical data management and analysis: po...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2400 | biostudies-arrayexpress
ProteomicsTDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
Single cell dataset of human motor neurons laser-captured from postmortem ALS and control tissues (1) ALS Pilot dataset (2) TDP43 stratified dataset Summary: Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-07 | MSV000092119 | MassIVE
TranscriptomicsProfiling wt SOD versus ALS SOD1(G93A) mutant
Whole-genome profiling of SH-SY5Y cells was done on neuroblastoma SH-SY5Y stably transfected with cDNAs coding for SOD1WT or the mutant SOD1(G93A) protein. Five wt SOD versus five mutant SOD
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21298 | biostudies-arrayexpress
ProteomicsEngineering Af1521 macro domain increases ADP-ribose binding affinity and leads to the identification of more ADP-ribosylated proteins
Protein ADP-ribosylation is a covalent, reversible post-translational modification that has important functions in several cellular mechanisms. The identification of modified proteins in cells has proven challenging and, due to the low abundance of protein ADP-ribosylation, has mainly been possible ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD016686 | Pride
Ap-ms Af1521 macro domain Adp-ribosylation Lc-ms/ms 
ProteomicsProteomic characterization of the heart and skeletal muscle reveals widespread Arginine ADP-ribosylation by the ectopic ADP-ribosyltransferase ARTC1
ADP-ribosylation has thus far been studied on the proteomic level mainly in cell lines and in combination with genotoxic stress. The clostridium-like ADP-ribosyltransferases (i.e. ARTC) are GPI-anchored or secreted proteins that are expressed in a highly tissue specific manner. Transcriptomic data r...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-17 | PXD008041 | Pride
Muscle Artc1 Ethcd Ptm Hcd Heart C2c12 Art1 Adp-ribosylation 
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