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ProteomicsMinD-RNase E interplay controls localization of polar mRNAs in E. coli
We have recently shown that the polar transcriptome of E. coli is unique compared to the membrane and cytosolic ones. Several factors were suggested to mediate mRNA localization to the membrane, but the mechanism of localizing mRNAs to the poles is not known. We combined a candidate system approach ...
ORGANISM(S): Escherichia coli 
2023-12-17 | PXD044814 | Pride
Lc-ms/ms Proteomics E coli Rna localization 
ProteomicsSystematic detection of amino acid substitutions in proteomes reveals a mechanistic basis of ribosome errors and selection for translation fidelity
The translation machinery and the genes it decodes co-evolved to achieve production throughput and accuracy. Nonetheless translation errors are frequent and they affect physiology and protein evolution. Mapping translation errors in proteomes and understanding their causes was hindered by lack of a ...
ORGANISM(S): Escherichia coli 
2019-07-29 | PXD014341 | Pride
Translation  ribosome errors  mispairing  misloading  mass spectrometry 
ProteomicsProteogenomic analysis of glioblstoma reveals survival related patterns
In the current work, we present the first proteogenomic dataset of GBM clinical samples to date. We have assembled a cohort of 87 GBM patients of varying survival rates and performed MS-based proteomics analysis as well as RNA-seq in order to identify the molecular differences associated with surviv...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD018024 | Pride
Proteogenomics Proteomics Mass spectrometry Glioblstoma Rna-seq 
UnknownMinD-RNase E interplay controls localization of polar mRNAs in E. coli.
Not available
S-EPMC10897333 | biostudies-literature
ProteomicsTumor-Associated Macrophages Promote Colorectal Tumor Development Through Remodeling of Its Extracellular Matrix
Extracellular matrix (ECM) structural and compositional abnormalities are a hallmark of many cancers. Tumor associated macrophages (TAM) are considered pivotal players in mounting pro-tumoral functions; yet, their role in tumor-ECM remodeling remains largely ambiguous. Using an orthotopic murine mod...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-26 | PXD002094 | Pride
Colorectal cancer Tumor microenvironment Extracellular matrix Tumor-associated macrophages Murine crc model 
UnknownMinD-RNase E interplay controls localization of polar mRNAs in E. coli
Not available
S-SCDT-10_1038-S44318-023-00026-9 | biostudies-other
UnknownDual role of E-cadherin in the regulation of invasive collective migration of mammary carcinoma cells.
Not available
S-EPMC5862898 | biostudies-literature
ProteomicsA systematic multi-omics investigation of breast cancer metabolism mapping its tiered regulation
Altered metabolism is a hallmark of cancer, but little is still known about its regulation. Here we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer cell-line across three different conditions. Integrating these multiomics data within a genome scale human me...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD006449 | Pride
Phosphoproteomics Breast cancer Proteomics Metabolomics Metabolic modeling 
ProteomicsBreast cancer tumors - System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis
The project analyzed 88 breast cancer clinical samples, including lymph node negative and positive primary tumors, lymph node metastases, and healthy tissue as control. All samples were combined with a super-SILAC mix that served as an internal standard for quantification.
ORGANISM(S): Homo sapiens (Human) 
2016-01-25 | PXD000815 | Pride
Er positive Lymph node negative Breast cance Luminal Lymph node positive 
Unknown2-Amino-5-nitro-N-[(E)-thio-phen-2-yl-methyl-idene]aniline.
Not available
S-EPMC3470223 | biostudies-literature
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