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UnknownAvelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study.
Not available
S-EPMC5493051 | biostudies-literature
UnknownBurden of Cardiomyopathic Genetic Variation in Lethal Pediatric Myocarditis.
Not available
S-EPMC8373803 | biostudies-literature
TranscriptomicsTranscriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells
The myometrium is an important reproductive tissue composed primarily of smooth muscle cells. Contractility of the myometrial smooth muscle cells during the estrous cycle and pregnancy is modulated by estrogen. Despite much research, little is known about the molecular mechanism by which estrogen re...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-51470 | biostudies-arrayexpress
UnknownAutosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis.
Not available
S-EPMC5551973 | biostudies-literature
GenomicsNational Heart, Lung, and Blood Institute (NHLBI) Bench to Bassinet Program: The Pediatric Cardiac Genetics Consortium (PCGC)

Multi-center, prospective observational cohort study of individuals with congenital heart defects (CHD). Phenotypic data and source DNA of probands, parents, and families of interest are being collected to investigate relationships between genetic factors and phenotypic and clinical outcomes in p...

phs000571.v1.p1 | EGA
TranscriptomicsMicroarray Profile of Gene Expression during Osteoclast Differentiation in Modeled Microgravity
Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study, we used NASA developed ground based Rotary Wall Vessel Bioreactor (RWV), Rotary Cell Culture System (RCCS) to simulate microgravity (μXg) conditio...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-21093 | biostudies-arrayexpress
TranscriptomicsExpression data from C2C12 cells with or without Smad3 overexpression
The goal of this study was to identify genes in C2C12 myoblasts whose expression was altered by overexpression of Smad3. Four total samples were analyzed. Two biological replicates were prepared from C2C12 cells infected with retroviral vector encoding wildtype Smad3 and exposed for 24 hours to 100 ...
ORGANISM(S): Mus musculus 
2011-10-20 | E-GEOD-30459 | biostudies-arrayexpress
TranscriptomicsExpression Data from Normal or Tumor Fibroblasts With or Without Ets2
The mechanisms involved in epithelium-stroma interactions remain poorly understood, despite the importance of the microenvironment during tumorigenesis. Here, we studied the role of the Ets2 transcription factor in tumor-associated fibroblasts in the MMTV-PyMT mammary tumor model. Inactivation of ...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-16989 | biostudies-arrayexpress
UnknownDrug screening identifies tazarotene and bexarotene as therapeutic agents in Multiple Sulfatase Deficiency
Not available
S-SCDT-10_15252-EMMM_202114837 | biostudies-other
TranscriptomicsBone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
Carcinoma-associated fibroblasts (CAFs) that express ?-smooth-muscle-actin (?SMA+) contribute to cancer progression, but their precise origin and role in tumorigenesis is not established. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-23548 | biostudies-arrayexpress
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