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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
GenomicsATR Is a Critical Dependency Gene Supporting Uveal Melanoma Cell Survival
ATR Is a Critical Dependency Gene Supporting Uveal Melanoma Cell Survival
PRJNA1414276 | ENA
ProteomicsMYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma
Multiple myeloma is an incurable hematological malignancy evolving from precursor states to advanced phases of the disease. MYC abnormalities play a critical role in the disease progression. Nevertheless, MYC lacks therapeutic drugability, thereby necessitating the exploration of alternative strateg...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050010 | Pride
Tmt spectrometry Myc U266 Gls1 Nampt Gene dependency Myc overexpression Cellular metabolism Multiple myeloma 
UnknownPartial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal.
Not available
S-EPMC10464129 | biostudies-literature
UnknownA model-based method for gene dependency measurement.
Not available
S-EPMC3400631 | biostudies-literature
TranscriptomicsMicroarray expression profiling of the Igf2 pathway dependency of Trp53 developmental and tumour phenotypes in mice
We tested whether loss of p53 function leads to insulin-like growth factor 2 (IGF2) pathway dependency in vivo in genetically defined mouse models. Unexpectedly we found lethality, due to post-natal lung haemorrhage, occurred in Igf2 paternal null allele female mice (Igf2-p) but only if derived from...
ORGANISM(S): Mus musculus 
2012-06-01 | E-MTAB-1001 | biostudies-arrayexpress
GenomicsRSK1 is an exploitable dependency in myeloid malignancies [CD14_RNAseq]
RSK1 is an exploitable dependency in myeloid malignancies [CD14_RNAseq]
PRJNA1195077 | ENA
UnknownInferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer.
Not available
S-EPMC3956890 | biostudies-literature
GenomicsRSK1 is an exploitable dependency in myeloid malignancies [CD34RNAseq]
RSK1 is an exploitable dependency in myeloid malignancies [CD34RNAseq]
PRJNA1195078 | ENA
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