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MetabolomicsInositol Pyrophosphates Mediate Chloroplast Lipid Remodeling and Nuclear Gene Repression during High-Light Acclimation in Chlamydomonas reinhardtii
Microalgae are photosynthetic organisms capable of autotrophic growth. Their applicability in multiple industrial fields has been largely studied, thanks to their ability to fixate CO2 into high added value organic products like fatty acids and carotenoids. However, our under-standing of the cellula...
2026-06-09 | MTBLS14720 | MetaboLights
MetabolomicsTranslational repression of viral RNA mediates arbovirus persistence in mosquitoes

Persistent infection of mosquito vectors is essential for the transmission of arboviruses, yet how these viruses produce sufficient progeny without compromising host cell fitness remains unclear. Arbovirus genomes exhibit suboptimal codon usage for both human and mosquito hosts, raising questions...

2026-02-12 | MTBLS12760 | MetaboLights
ModelsGlucose Repression Signaling 2009
Background In the yeast Saccharomyces cerevisiae, the presence of high levels of glucose leads to an array of down-regulatory effects known as glucose repression. This process is complex due to the presence of feedback loops and crosstalk between different pathways, complicating the use of intuitive...
3511 | Cell Collective
TranscriptomicsA large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response
Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of ...
ORGANISM(S): Mus musculus 
2010-08-09 | E-GEOD-21761 | biostudies-arrayexpress
TranscriptomicsEpigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Adult-onset diseases can be associated with in utero events, but mechanisms for such temporally distant dysregulation of organ function remain unknown. The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive histone marks during development that persist into ...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-30076 | biostudies-arrayexpress
TranscriptomicsEstrogen-mediated Epigenetic Repression of Large Chromosomal Regions through DNA Looping
The current concept of epigenetic repression is based on one repressor unit corresponding to one silent gene. This notion, however, cannot adequately explain concurrent silencing of multiple loci observed in large chromosome regions. The long-range epigenetic silencing (LRES) can be a frequent occur...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21068 | biostudies-arrayexpress
ProteomicsConserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
Long non-coding RNAs (lncRNAs) are components of epigenetic control mechanisms that ensure appropriate and timely gene expression. The functions of lncRNAs are often mediated through associated gene regulatory activities, but how lncRNAs are distinguished from other RNAs and recruit effector comple...
ORGANISM(S): Homo sapiens (Human) 
2020-04-07 | PXD018373 | Pride
Ars2 Rime Lncrna 
TranscriptomicsTranscriptional response of steady-state Escherichia coli cultures to a glucose pulse, in order to elucidate the role of post-transcriptional regulation during carbon catabolite repression
Gene-expression measurements were made over a 60 minute time course as steady state E. coli cells were subjected to a pulse of glucose.
ORGANISM(S): Escherichia coli 
2015-06-29 | E-MTAB-2398 | biostudies-arrayexpress
GenomicsActivation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downreg...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-44672 | biostudies-arrayexpress
TranscriptomicsA network of transcriptional repression specifies muscle fibre type in the zebrafish embryo
The zebrafish u-boot (ubo) gene encodes the transcription factor Prdm1, which is essential for the specification of the primary slow twitch muscle fibres that derive from adaxial cells. Here we show that Prdm1 executes this function by acting as a transcriptional repressor. Expression of the slow tw...
ORGANISM(S): Danio rerio 
2010-05-25 | E-GEOD-10883 | biostudies-arrayexpress
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