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ProteomicsOmega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice
Soybean oil consumption is increasing worldwide and parallels the rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance and fatty liver in mice. Here, we show that the genetically modified s...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-08 | MSV000081149 | MassIVE
TranscriptomicsJuvenile obesity in Ossabaw swine produces artery-specific transcriptional changes
We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivas...
ORGANISM(S): Sus scrofa 
2013-05-29 | E-GEOD-41636 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fat biopsies from monozygotic twins discordant for body mass index to elucidate the effects of acquired obesity
Elucidating the effects of acquired obesity by comparison of fat biopsies from monozygotic twins discordant for BMI.
ORGANISM(S): Homo sapiens 
2008-02-15 | E-MEXP-1425 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adipocytes and stromo-vascular fraction from subcutaneous and intraabdominal mouse adipose tissue
Obesity is an epidemic health problem worldwide that impacts the risk and prognosis of many diseases. However, not all obese patients have the same risk of developing these disorders. Individuals with peripheral obesity, i.e., fat distributed subcutaneously, are at little or no risk of the common me...
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-8505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C2C12 myotubes treated overnight with 500 uM palmitate or 1% bovine serum albumin control to identify mediators of obesity-linked reductions in PGC-1
To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Exper...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6766 | biostudies-arrayexpress
UnknownUnique Gut Microbiome Signatures Depict Diet-Versus Genetically Induced Obesity in Mice.
Not available
S-EPMC7279357 | biostudies-literature
TranscriptomicsDiet-induced obesity Kozak1_ABI_ING
The experimental goals of this study were to determine differences in adipose tissue gene expression in genetically identical mice that have variability in their susceptibility towards diet-induced obesity following 4 weeks feeding a high saturated fat diet. Keywords: comparative gene expression ana...
ORGANISM(S): Mus musculus 
2006-04-28 | GSE4692 | GEO
UnknownChanges in gene expression foreshadow diet-induced obesity in genetically identical mice.
Not available
S-EPMC1464831 | biostudies-literature
ProteomicsOrganoid-trasplant model systems to study in vivo the effects of obesity on the pancreatic carcinogenesis
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality among adults in developed countries. The discovery of the most common genetic alterations as well as the development of organoids models of pancreatic cancer have provided insight into the fundamental path...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018362 | Pride
Carcinogenesis Obesity Organoid models Adipokines Pancreatic cancer 
UnknownDiet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.
Not available
S-EPMC4540493 | biostudies-literature
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