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TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-58782 | biostudies-arrayexpress
TranscriptomicsCharacterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells
Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested th...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-41296 | biostudies-arrayexpress
GenomicsAnalysis of transcriptomic responses of genotoxic and non-genotoxic stress in human lymphoblastoid TK6 cells
Analysis of transcriptomic responses of genotoxic and non-genotoxic stress in human lymphoblastoid TK6 cells
PRJNA768817 | ENA
TranscriptomicsTranscription profiling of primary mouse hepatocytes reveals classification for genotoxic and non-genotoxic carcinogens by gene expression improves with exposure time
The prediction of possible carcinogenicity of chemicals for humans represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk at only limited reliability while simultaneously being expensive and long-lasting. In order to seek for alternatives, in the present study, the abil...
ORGANISM(S): Mus musculus 
2010-06-09 | E-MEXP-2209 | biostudies-arrayexpress
TranscriptomicsExpression data from CD-1 mouse liver samples obtained from in-vivo treatment with genotoxic carcinogens, non-genotoxic carcinogens or non-hepatocarcinogens.
Assessing the carcinogenic potential of drug candidates is a costly procedure which requires the life-long treatment of rodents at different dose levels. A promising approach, which may to a certain degree reduce the need for animal studies in the future is toxicogenomics. The idea is to employ micr...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-44783 | biostudies-arrayexpress
TranscriptomicsGene expression profiling to recognize specific features of non-genotoxic carcinogens
The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different mod...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-44088 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51172 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [DEX]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51174 | biostudies-arrayexpress
GenomicsBCL6 Enables Cancer Cells to Evade Genotoxic Stress
BCL6 Enables Cancer Cells to Evade Genotoxic Stress
PRJNA679550 | ENA
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