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ProteomicsGephyrin interactome from mouse brain lysates using anti-gephyrin antibody and anti-gephyrin DARPins
In order to understand the protein interactors of the inhibitory synaptic scaffolding protein gephyrin, we precipitated gephyrin protein complexes from adult mouse brain lysates of both sexes using both a commercial anti-gephyrin antibody (clone 3B11), as well as anti-gephyrin Designed Ankyrin Repea...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-01 | PXD033641 | Pride
Ap-ms Mus musculus 3b11 C56bl/6j mouse Gephyrin Gphn Designed ankyrin repeat domain Darpin Interactome Lc-ms/ms 
ProteomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we uncover an extensive diversity of GPHN transcripts that are tightly controlled by splicing during mouse and human brain development. P...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-28 | PXD033751 | Pride
Splice variants Gephyrin Inhibitory synapses 
ProteomicsIdentifying altered mouse gephyrin interactome after sleep deprivation
GABAergic transmission controls cortical sleep, however the molecular determinants of GABAergic control of this phenomenon are unknown. We used immunoprecipitation of the inhibitory postsynaptic protein gephyrin to identify gephyrin interactors at ZT6 (sleep) and ZT6 with sleep deprivation (ZT6SD).
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD048929 | Pride
Mouse Gephyrin interactome Sleep deprivation 
UnknownImpaired formation of high-order gephyrin oligomers underlies gephyrin dysfunction-associated pathologies.
Not available
S-EPMC7822942 | biostudies-literature
GenomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Alternative splicing generates a myriad of Gephyrin isoforms at iPSD
PRJEB49417 | ENA
GenomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Alternative splicing generates a myriad of Gephyrin isoforms at iPSD
PRJEB49420 | ENA
UnknownCollybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.
Not available
S-EPMC3148131 | biostudies-literature
UnknownGephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.
Not available
S-EPMC8467468 | biostudies-literature
UnknownStructural basis of dynamic glycine receptor clustering by gephyrin.
Not available
S-EPMC449768 | biostudies-literature
UnknownGephyrin clustering is required for the stability of GABAergic synapses.
Not available
S-EPMC2464357 | biostudies-literature
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