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ProteomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we uncover an extensive diversity of GPHN transcripts that are tightly controlled by splicing during mouse and human brain development. P...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-28 | PXD033751 | Pride
Splice variants Gephyrin Inhibitory synapses 
ProteomicsGlycine receptor complex analysis using immunoprecipitation-blue native gel electrophoresis-mass spectrometry
The pentameric glycine receptor (GlyR), comprising the α1 and β subunits, is a major inhibitory ionotropic receptor in brainstem and spinal cord. GlyRs interact with gephyrin (GPHN), a scaffold protein that anchors the GlyR in the plasma membrane and enables it to form clusters in glycinergic postsy...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD017151 | Pride
Blue native gel electrophoresis Proteomics Protein complex Glycine receptor Iqsec3 
UnknownComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity.
Not available
S-EPMC9206673 | biostudies-literature
UnknownCorrelated Expression of the Opsin Retrogene LWS-R and its Host Gene in Two Poeciliid Fishes.
Not available
S-EPMC9579955 | biostudies-literature
GenomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Alternative splicing generates a myriad of Gephyrin isoforms at iPSD
PRJEB49417 | ENA
GenomicsComplex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity
Alternative splicing generates a myriad of Gephyrin isoforms at iPSD
PRJEB49420 | ENA
UnknownmiRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.
Not available
S-EPMC11549329 | biostudies-literature
UnknownmiRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.
Not available
S-EPMC10760056 | biostudies-literature
UnknownGephyrin and CYP2C9 Genetic Polymorphisms in Patients with Pharmacoresistant Epilepsy.
Not available
S-EPMC8437390 | biostudies-literature
UnknownAutoantibodies as predictors for immune-related adverse events in checkpoint inhibition therapy of metastatic melanoma.
Not available
S-EPMC12853468 | biostudies-literature
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