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TranscriptomicsTranscription profiling of human peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension
Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension.
ORGANISM(S): Homo sapiens 
2007-09-21 | E-GEOD-703 | biostudies-arrayexpress
TranscriptomicsIdentification of Copy Number Variants in Patients with Hypoplastic Left Heart Syndrome and Other Congenital Heart Defects
Hypoplastic left heart syndrome (HLHS) is a heterogeneous, lethal combination of congenital malformations that result in a heart unable to sustain systemic circulation. The genetic determinants of this disorder are largely unknown. Evidence of copy number variants (CNVs) contributing to the genetic ...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-66032 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsApplication of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions
Chromosomal instability is central to the process of carcinogenesis. The detection of somatic chromosomal alterations in small premalignant lesions genome-wide remains challenging since sample heterogeneity dilutes the aberrant cell information. We introduced an analytic metric termed "delta-θ&...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-43168 | biostudies-arrayexpress
UnknownCirculating RNA transcripts identify therapeutic response in cystic fibrosis lung disease.
Not available
S-EPMC2577728 | biostudies-literature
TranscriptomicsTranscription profiling of bronchoalveolar lavage cells from AJ mice treated with urethane vs. controls
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis of bronchoalveolar lavage cells from control or urethane treated mice. A unique macrophage expression signature in the lung tumor micro...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of untreated mouse lung broncheolar lavage samples (part of wider carcinogenesis study)
This SuperSeries is composed of the following subset Series:; GSE7244: Expression data from AJ mouse control lung tissue; GSE7258: Expression data of bronchoalveolar lavage cells from control or urethane treated AJ mice Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal mouse lung from age matched untreated controls from AJ mice were from two time points 24 to 26 weeks (N) or 42 weeks (N42) after saline injection
AJ mouse is susceptible to lung carcinogenesis from urethane treatment and is a good model for human adenocarcinoma. We completed a study using microarray analysis to identify a unique macrophage expression signature in the lung tumor microenvironment. Experiment Overall Design: RNA from lung tissu...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung tissue from emphysema and control patients
Gene expression profiling of lung tissue from undiseased (NML), 'usual' emphysema (EML), and Alpha-1 Antitrypsin Deficiency-related emphysema (ADL).
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1122 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20206 | biostudies-arrayexpress
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