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TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therapeutic ...
ORGANISM(S): Mus musculus 
2010-12-27 | E-GEOD-26317 | biostudies-arrayexpress
TranscriptomicsMolecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy
The molecular basis of epileptogenesis is poorly characterized. Studies in humans and animal models have identified an electrophysiological signature that precedes the onset of epilepsy, which has been termed fast ripples (FRs) based on its frequency. Multiple lines of evidence implicate regions gen...
ORGANISM(S): Rattus norvegicus 
2015-05-01 | E-GEOD-68430 | biostudies-arrayexpress
TranscriptomicsGene expression study in choroid plexus
The choroid plexus (CP) constitutes one of the blood–brain barriers – the blood cerebrospinal fluid barrier. It is formed by a monolayer of epithelial cells located within the brain ventricles and in addition to be responsible for the formation of the cerebrospinal fluid (CSF) is ideally positioned ...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-23714 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons: young
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24440 | biostudies-arrayexpress
TranscriptomicsSprouting transcriptome in cortical neurons: aged
Selective isolation of total RNA and then whole genome expression analysis of sprouting neurons in peri-infarct cortex of the adult rat after stroke, compared to adjacent neurons that have not sprouted a new connection, in young adult (2 months) and aged (2 years) animals. Two different fluorescent ...
ORGANISM(S): Rattus norvegicus 
2010-11-15 | E-GEOD-24441 | biostudies-arrayexpress
UnknownGenome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways.
Not available
S-EPMC3856943 | biostudies-literature
UnknownAnalysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.
Not available
S-EPMC7735761 | biostudies-literature
UnknownThe Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.
Not available
S-EPMC5924568 | biostudies-literature
UnknownCorrespondence between Resting-State Activity and Brain Gene Expression.
Not available
S-EPMC4694561 | biostudies-literature
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