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MetabolomicsAmniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome
Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related in...
2026-07-25 | MTBLS14946 | MetaboLights
MetabolomicsGut Microbiota Mediates Maternal PM2.5 Exposure-induced Neurodevelopmental Disorder in offspring via Disturbing the Glutamate Metabolism: Evidence from Multiomics Analysis

While accumulating evidence links maternal PM2.5 exposure to offspring neurodevelopmental impairments, yet the underlying biological pathways require further elucidation. To address this, female ICR mice are exposed to filtered air (FA) or concentrated ambient particulate matter (CAP) for three ...

2026-01-05 | MTBLS13599 | MetaboLights
GenomicsmRNA and microRNA Transcriptional Profiling of Gestation Day 21 Female Rat Liver and Placenta following Gestation Day 6 - 20 Ketoconazole Exposure
mRNA and microRNA Transcriptional Profiling of Gestation Day 21 Female Rat Liver and Placenta following Gestation Day 6 - 20 Ketoconazole Exposure
PRJNA823568 | ENA
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the fetal rhesus monkey uterus from early to late gestation and the effects of in utero exposure to BPA
We used the rhesus monkey (Macaca mulatta) as our animal model for the current study with two goals: to characterize the changes in histology and gene expression from early to late gestation (prenatal uterine organogenesis) and to determine if there are effects of prenatal exposure to bisphenol A (B...
ORGANISM(S): Macaca mulatta 
2014-05-22 | E-GEOD-38421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Cadmium induced defects in the embryo 5 h after maternal Cd exposure in the absence or presence of Zn pretreatment
Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis to investigate gene expressi...
ORGANISM(S): Mus musculus 
2006-04-11 | E-MEXP-529 | biostudies-arrayexpress
TranscriptomicsmRNA and microRNA Transcriptional Profiling of Gestation Day 21 Female Rat Liver and Placenta following Gestation Day 6 - 20 Ketoconazole Exposure
We report the RNAseq-based mRNA and microRNA transcriptome profiles of gestation day 21 female rat liver and placenta following oral ketoconazole exposure from gestation day 6 to 20. A treatment-related change in mRNA and microRNA levels was observed in both liver and placenta.
ORGANISM(S): Rattus norvegicus 
2022-05-02 | GSE200184 | GEO
GenomicsCannabidiol (CBD) exposure during gestation leads impaired cardiac function exclusively in male rat offspring
Cannabidiol (CBD) exposure during gestation leads impaired cardiac function exclusively in male rat offspring
PRJNA1011303 | ENA
ProteomicsZika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts
Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque trophoblast stem cells (TSC) that can be differentiated into ...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2022-05-20 | PXD033289 | Pride
Exosome Extracellular vesicle Trophoblast Placenta Zika virus 
TranscriptomicsParental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure
Adolescent binge alcohol exposure has been previously shown to have long-lasting effects on the expression of hypothalamic genes that regulate the stress response, even in the absence of subsequent adult alcohol exposure. Those data suggested that alcohol can induce permanent gene expression changes...
ORGANISM(S): Rattus norvegicus 
2014-03-19 | E-GEOD-53028 | biostudies-arrayexpress
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