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GenomicsGfpt2 Regulates Fibroblast Activation by Glutathione Metabolism
Gfpt2 Regulates Fibroblast Activation by Glutathione Metabolism
PRJNA1485076 | ENA
ProteomicsGlutamine-fructose-6-phosphate transaminase 2 (GFPT2) is upregulated in breast epithelial-mesenchymal transition and involved in oxidative stress regulation.
Epithelial-mesenchymal transition (EMT) is a diverse and dynamic biological process which is involved in cancer progression. It is important for carcinoma cells during invasion and metastasis. EMT has been in the spotlight for cancer cells to disseminate to distant organs by gaining partial EMT phen...
ORGANISM(S): Homo sapiens (Human) 
2022-01-05 | PXD025858 | Pride
Metabolism Breast cancer Emt Proteomics Oxidative stress Claudin-low Gfpt2 
ProteomicsGlutamine-fructose-6-phosphate transaminase 2 (GFPT2) is upregulated in breast epithelial-mesenchymal transition and involved in oxidative stress regulation.
Epithelial-mesenchymal transition (EMT) is a diverse and dynamic biological process which is involved in cancer progression. It is important for carcinoma cells during invasion and metastasis. EMT has been in the spotlight for cancer cells to disseminate to distant organs by gaining partial EMT phen...
ORGANISM(S): Homo sapiens (Human) 
2022-01-05 | PXD025600 | Pride
Metabolism Breast cancer Emt Proteomics Oxidative stress Claudin-low Gfpt2 
GenomicsGFPT2 knockdown effects on the tumor immune microenvironment though scRNA-seq
GFPT2 knockdown effects on the tumor immune microenvironment though scRNA-seq
PRJNA1080523 | ENA
TranscriptomicsGfpt2 Regulates Fibroblast Activation by Glutathione Metabolism
Aims: During fibroblast activation, the cell undergoes metabolic reprogramming to increase glycolysis and support increased cellular growth. The role of many ancillary metabolic pathways in cardiac fibroblasts remains poorly defined. Here we investigate the role of Gfpt2, the rate-limiting enzyme of...
ORGANISM(S): Mus musculus 
2026-09-10 | GSE337431 | GEO
TranscriptomicsGFPT2 knockdown effects on the tumor immune microenvironment though scRNA-seq
Through comprehensive genetic and pharmacological analyses across various models, we have identified glutamine fructose-6-phosphate transaminase 2 (GFPT2) as a key facilitator of immune evasion in EGFR-mutated NSCLC. GFPT2 escalates the expression and glycosylation of PD-L1, PVR and CD276, bolsterin...
ORGANISM(S): Mus musculus 
2024-04-19 | GSE259244 | GEO
UnknownGFPT2 promotes metastasis and forms a positive feedback loop with p65 in colorectal cancer.
Not available
S-EPMC7471343 | biostudies-literature
UnknownGFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Not available
S-EPMC8970586 | biostudies-literature
UnknownGFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer.
Not available
S-EPMC11499537 | biostudies-literature
UnknownCancer-associated fibroblast expression of glutamine fructose-6-phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer.
Not available
S-EPMC10397376 | biostudies-literature
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