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TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32904 | biostudies-arrayexpress
ProteomicsN-Linked Glycoprotein Profiles of Human Breast Claudin-Low Malignant Cell Lines
Secreted proteins and transmembrane proteins with extracellular domains are frequently glycosylated; this group of proteins includes those that participate in the various intercellular junctions and signaling pathways of an epithelium. In this study we characterized the differences in glycoprotein ...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005292 | Pride
Human Breast Lc-msms Claudin-low Cell line N-linked Glycoprotein 
TranscriptomicsExpression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-62230 | biostudies-arrayexpress
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human]
The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-32727 | biostudies-arrayexpress
TranscriptomicsComparative oncogenomics identifies breast tumors enriched in functional tumor initiating cells
The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derive...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-27101 | biostudies-arrayexpress
GenomicsHighly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
PRJNA660961 | ENA
GenomicsRNA Sequencing dataset of Claudin-low Breast Cancer Cell Lines with Neuropilin-1 Knockdown
RNA Sequencing dataset of Claudin-low Breast Cancer Cell Lines with Neuropilin-1 Knockdown
PRJNA1107597 | ENA
GenomicsAn EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis
An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis
PRJNA727014 | ENA
TranscriptomicsHighly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem cell-like and mesenchymal features. Little is known about the cellular origin and oncogenic drivers that promote claudin-low breast cancer. In this s...
ORGANISM(S): Mus musculus 
2021-05-05 | GSE157333 | GEO
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